A class-imbalanced classifier is a decision rule to predict the class membership of new
samples from an available data set where the class sizes differ considerably. When the class …

The inflammatory bowel diseases are complex diseases caused by environmental,
immunological, and genetic factors. Vitamin D status is low in patients with inflammatory bowel …

Objectives This article summarizes past and current data mining activities at the United
States Food and Drug Administration (FDA). Target audience We address data miners in all …

Over the last decade, the introduction of microarray technology has had a profound impact
on gene expression research. The publication of studies with dissimilar or altogether …

Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers characterized
by distinct transcriptional patterns, biology, and immune composition. TNBCs subtypes …

Background The acceptance of microarray technology in regulatory decision-making is
being challenged by the existence of various platforms and data analysis methods. A recent …

Background Many researchers are concerned with the comparability and reliability of
microarray gene expression data. Recent completion of the MicroArray Quality Control (MAQC) …

Testing for significance with gene expression data from DNA microarray experiments involves
simultaneous comparisons of hundreds or thousands of genes. If R denotes the number of …

Ovaries from National Toxicology Program Reproductive Assessment by Continuous Breeding
(RACB) bioassays were used to directly compare differential ovarian follicle counts and …

Motivation: A microarray experiment is a multi-step process, and each step is a potential
source of variation. There are two major sources of variation: biological variation and technical …