From over 100 children studied with 2‐deoxy‐2{ 18 F}fluoro‐D‐glucose and positron
emission tomography we selected 29 children (aged 5 days to 15.1 years) who had suffered …

Background Tuberous sclerosis complex is highly variable in clinical presentation and
findings. Disease manifestations continue to develop over the lifetime of an affected individual. …

Early global deprivation of institutionalized children may result in persistent specific cognitive
and behavioral deficits. In order to examine brain dysfunction underlying these deficits, we …

Studies with positron emission tomography indicate that the human brain undergoes a
period of postnatal maturation that is much more protracted than previously suspected. In the …

Background Tuberous sclerosis complex is a genetic disorder affecting every organ system,
but disease manifestations vary significantly among affected individuals. The diverse and …

2-Deoxy-2[ 18 F]fluoro-D-glucose positron emission tomography performed in human infants
during development revealed progressive changes in local cerebral glucose utilization. In …

Serotonin content, serotonin uptake sites, and serotonin receptor binding measured in animal
studies are all higher in the developing brain, compared with adult values, and decline …

Positron emission tomography (PET) of local cerebral glucose metabolism in 13 children
with infantile spasms of undetermined cause (cryptogenic spasms) revealed unilateral …

OBJECTIVES. We previously reported that children who were subjected to early socioemotional
deprivation in Romanian orphanages showed glucose hypometabolism in limbic and …

Based on reports of increased platelet serotonin in 30 to 50% of autistic subjects, abnormal
serotonergic neurotransmission may be important in the pathogenesis of autism. However, …