Clinical Value of Absolute Quantification of Myocardial Perfusion With 15O-Water in Coronary Artery Disease

…, H Ukkonen, A Saraste, HT Sipilä… - Circulation …, 2011 - Am Heart Assoc
Background— The standard interpretation of perfusion imaging is based on the assessment
of relative perfusion distribution. The limitations of that approach have been recognized in …

[HTML][HTML] Human brown adipose tissue [15O]O2 PET imaging in the presence and absence of cold stimulus

…, T Tolvanen, V Oikonen, J Teuho, HT Sipilä… - European Journal of …, 2016 - Springer
Purpose Brown adipose tissue (BAT) is considered a potential target for combatting obesity,
as it produces heat instead of ATP in cellular respiration due to uncoupling protein-1 (UCP-1…

Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a pet study with nitric oxide and cyclooxygenase inhibition

H Ilkka, S Bengt, K Jukka, HT Sipilä… - American Journal …, 2011 - journals.physiology.org
The aim of the present study was to determine the effect of nitric oxide and prostanoids on
microcirculation and oxygen uptake, specifically in the active skeletal muscle by use of …

Positron emission tomography examination of cerebral blood flow and glucose metabolism in young CADASIL patients

…, M Pöyhönen, H Kalimo, M Viitanen, HT Sipilä… - Stroke, 2004 - Am Heart Assoc
Background and Purpose— CADASIL causes repeated ischemic strokes leading to subcortical
vascular dementia. The purpose of this study was to assess whether cerebral blood flow (…

Dual-gated cardiac PET–clinical feasibility study

…, M Pietilä, J Kiss, E Hoppela, HT Sipilä… - European journal of …, 2010 - Springer
Purpose Both respiratory and cardiac motions reduce image quality in myocardial imaging.
For accurate imaging of small structures such as vulnerable coronary plaques, simultaneous …

Effects of adenosine, exercise, and moderate acute hypoxia on energy substrate utilization of human skeletal muscle

…, K Kaskinoro, JE Peltonen, HT Sipilä… - American Journal …, 2012 - journals.physiology.org
Glucose metabolism increases in hypoxia and can be influenced by endogenous adenosine,
but the role of adenosine for regulating glucose metabolism at rest or during exercise in …

Myocardial blood flow and its transit time, oxygen utilization, and efficiency of highly endurance-trained human heart

…, M Luotolahti, P Luoto, V Oikonen, HT Sipilä… - Basic research in …, 2014 - Springer
Highly endurance-trained athlete’s heart represents the most extreme form of cardiac
adaptation to physical stress, but its circulatory alterations remain obscure. In the present study, …

Intrapericardial, but not extrapericardial, fat is an independent predictor of impaired hyperemic coronary perfusion in coronary artery disease

…, M Saraste, M Pietilä, HT Sipilä… - … , and vascular biology, 2011 - Am Heart Assoc
Objective— To measure intrapericardial fat (IPF), extrapericardial fat (EPF), and myocardial
perfusion (MBF) in patients with and without coronary artery disease (CAD), hypothesizing …

Dual gated PET/CT imaging of small targets of the heart: Method description and testing with a dynamic heart phantom

T Kokki, HT Sipilä, M Teräs, T Noponen… - Journal of nuclear …, 2010 - Elsevier
Background In PET imaging respiratory and cardiac contraction motions interfere the
imaging of heart. The aim was to develop and evaluate dual gating method for improving the …

[HTML][HTML] Assessment of blood flow with 68Ga-DOTA PET in experimental inflammation: a validation study using 15O-water

…, M Tarkia, V Oikonen, HT Sipilä… - American journal of …, 2014 - ncbi.nlm.nih.gov
Increased blood flow and vascular permeability are key events in inflammation. Based on
the fact that Gadolinium-1, 4, 7, 10-tetraazacyclododecane-N, N ‘, N ‘‘, N ‘‘‘-tetraacetic acid (Gd-…