Relationship between atrophy and β‐amyloid deposition in Alzheimer disease

…, RN Martins, GJ O'Keefe, O Salvado… - Annals of …, 2010 - Wiley Online Library
Objective Elucidating the role of aggregated β‐amyloid in relation to gray matter atrophy is
crucial to the understanding of the pathological mechanisms of Alzheimer disease and for the …

Correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in gliomas using 18F-fluoromisonidazole, 18F-FDG PET, and immunohistochemical …

…, A Papenfuss, A Hannah, GJ O'Keefe… - Journal of Nuclear …, 2006 - Soc Nuclear Med
PET offers a noninvasive means to assess neoplasms, in view of its sensitivity and accuracy
in staging tumors and potentially in monitoring treatment response. The aim of this study …

High striatal amyloid β-peptide deposition across different autosomal Alzheimer disease mutation types

…, T Miki, H Shimada, GJ O'Keefe… - Archives of …, 2009 - jamanetwork.com
Background Supported by compelling genetic data regarding early-onset familial Alzheimer
disease (AD), the amyloid β-peptide (Aβ)–centric theory holds that Aβ is involved in the …

Lack of correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in non–small cell lung cancer assessed by 18F-fluoromisonidazole and 18F …

…, JI Sachinidis, THC Saunder, GJ O'Keefe… - Journal of Nuclear …, 2006 - Soc Nuclear Med
PET offers a noninvasive means to assess neoplasms, in view of its sensitivity and accuracy
in staging tumors and potentially in monitoring treatment response. The aim of this study …

Radiation dose to PET technologists and strategies to lower occupational exposure

…, T Mi, SU Berlangieri, GJ O'Keefe… - Journal of nuclear …, 2005 - Soc Nuclear Med
Objective: The use of PET in Australia has grown rapidly. We conducted a prospective study
of the radiation exposure of technologists working in PET and evaluated the occupational …

Independent contribution of temporal β-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease

…, KA Ellis, P Bourgeat, G Jones, GJ O'Keefe, O Salvado… - Brain, 2011 - academic.oup.com
The relationship between β-amyloid deposition and memory deficits in early Alzheimer’s
disease is unresolved, as past studies show conflicting findings. The present study aims to …

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis (thiosemicarbazonato) copper (ii) complex that binds to amyloid-β plaques

…, MT Fodero-Tavoletti, GJ O'Keefe… - Chemical …, 2010 - pubs.rsc.org
A bis(thiosemicarbazonato)copper(II) complex with an appended stilbene functional group
binds to amyloid-β plaques that are associated with Alzheimer's disease. The complex has …

Radiation dosimetry of β-amyloid tracers 11C-PiB and 18F-BAY94-9172

GJ O'Keefe, TH Saunder, S Ng… - Journal of Nuclear …, 2009 - Soc Nuclear Med
β-Amyloid (Aβ) imaging has great potential to aid in the diagnosis of Alzheimer disease and
the development of therapeutics. The radiation dosimetry of Aβ radioligands may influence …

[HTML][HTML] Molecular imaging of T cell co-regulator factor B7-H3 with 89Zr-DS-5573a

…, N Guo, Z Liu, HK Gan, A Rigopoulos, GJ O'Keefe… - Theranostics, 2018 - ncbi.nlm.nih.gov
B7-H3 is a transmembrane protein widely expressed in a variety of cancers and has been
shown to play a role in anti-tumor immunity. This study aims to develop a molecular imaging …

Accuracy of dose calibrators for 68Ga PET imaging: unexpected findings in a multicenter clinical pretrial assessment

…, MS Hofman, NJ Forwood, GJ O'Keefe… - Journal of Nuclear …, 2018 - Soc Nuclear Med
We report the discovery of a systematic miscalibration during the work-up process for site
validation of a multicenter clinical PET imaging trial using 68 Ga, which manifested as a …