A single dose of psilocybin, a psychedelic and serotonin 2A receptor (5-HT 2A R) agonist,
may be associated with antidepressant effects. The mechanism behind its antidepressive …

Manipulations of the serotonin levels in the brain can affect impulsive behavior and influence
our reactivity to conditioned reinforcers. Eating, tobacco smoking, and alcohol consumption …

Background and Purpose—Under normal circumstances, autoregulation maintains cerebral
blood flow (CBF) constant within a wide range of mean arterial pressure (MAP). It remains …

Remarkable progress has come from whole-brain models linking anatomy and function.
Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human …

Background: Psilocybin is a serotonergic psychedelic with psychoactive effects mediated by
serotonin 2A receptor (5-HT2AR) activation. It produces an acute psychedelic altered state …

Background: Psilocybin is a psychedelic drug that has shown lasting positive effects on
clinical symptoms and self-reported well-being following a single dose. There has been little …

Psilocybin and other serotonergic psychedelics have re-emerged as therapeutics for
neuropsychiatric disorders, including addiction. Psilocybin induces long-lasting effects on behavior, …

This study validates transcranial Doppler sonography (TCD) for determination of the lower
limit of cerebral blood flow (CBF) autoregulation and establishes a relation between global …

Cerebral blood flow (CBF) and cerebral metabolic rate are normally coupled, that is an
increase in metabolic demand will lead to an increase in flow. However, during functional …

Clinical research into serotonergic psychedelics is expanding rapidly, showing promising
efficacy across myriad disorders. Resting-state functional magnetic resonance imaging (rs-fMRI…