Oxidative stress (OS) has been implicated in the pathophysiology of many neurological,
particularly neurodegenerative diseases. OS can cause cellular damage and subsequent cell …

The identification of genetic causes for Mendelian disorders has been based on the collection
of multi-incident families, linkage analysis, and sequencing of genes in candidate intervals…

Background A therapy that slows disease progression is the major unmet need in Parkinson's
disease. Methods In this double-blind trial, we examined the possibility that rasagiline has …

Accumulating data indicate that oxidative stress (OS) plays a major role in the pathogenesis
of multiple sclerosis (MS). Reactive oxygen species (ROS), leading to OS, generated in …

Free radicals are highly reactive molecules generated predominantly during cellular respiration
and normal metabolism. Imbalance between cellular production of free radicals and the …

To revalidate the Freezing of Gait Questionnaire (FOG‐Q), patients with Parkinson's disease
(PD) were randomly assigned to receive rasagiline (1 mg/day) (n = 150), entacapone (200 …

Background Multiple system atrophy (MSA) is a fatal and still poorly understood degenerative
movement disorder that is characterised by autonomic failure, cerebellar ataxia, and …

Levodopa is the most effective symptomatic agent in the treatment of Parkinson's disease (PD)
and the “gold standard” against which new agents must be compared. However, there …

Various doses of 6-hydroxydopamine injected into the rat substantia nigra produced partial,
dose-dependent lesions of the dopaminergic nigrostriatal tract. The resulting reduction in …

Amyotrophic lateral sclerosis (ALS) is a lethal disease, characterized by progressive death
of motor neurons with unknown etiology. Evidence from animal models indicates that …