BACKGROUND: Prior research has shown a decrease in medication adherence as dosing
frequency increases; however, meta-analyses have not been able to demonstrate a …

Importance Combined use of inhaled corticosteroids and long-acting β-agonists (LABAs) as
the controller and the quick relief therapy termedsingle maintenance and reliever therapy(…

News and social media platforms have implicated dietary supplements in the treatment and
prevention of coronavirus disease 2019 (COVID-19). During this pandemic when information …

Background: Many cardiovascular diseases (CVDs) require patients to take one or more
long term medications, often administered multiple times a day. We sought to determine the …

Introduction When first line therapy with metformin is insufficient for patients with type 2 diabetes
(T2D), the optimal adjunctive therapy is unclear. We assessed the efficacy and safety of …

Introduction While chloroquine, a derivative of quinine, has been used as an antimalarial for
70 years, hydroxychloroquine is now used to treat conditions such as rheumatoid arthritis …

BACKGROUND: Plant sterols and stanols are plant steroids with a similar chemical structure
and cellular function to human cholesterol, and are recommended as dietary modifiers of …

Importance Long-acting muscarinic antagonists (LAMAs) are a potential adjunct therapy to
inhaled corticosteroids in the management of persistent asthma. Objective To conduct a …

Background: Limited data define what constitutes a clinically significant change on the Timed
25-Foot Walk (T25FW) in multiple sclerosis (MS); however, most studies suggest a value of …

OBJECTIVES To assess adverse effects of pharmacologic antidepressants for treatment of
major depressive disorder (MDD) in adults 65 years of age or older. DESIGN Systematic …