This study evaluates effects of anesthesia on 18 F-FDG (FDG) uptake in mouse brain and
heart to establish the basic conditions of small animal PET imaging. Prior to FDG injection, 12 …

Peer-reared (PR) rhesus monkeys with early maternal separation later exhibit aggressiveness,
impaired impulse control, alcohol abuse, and low CSF 5-hydroxyindoleacetic acid. This …

Purpose The purpose of this study was to evaluate the capacity of [ 11 C]6-OH-BTA-1 and
positron emission tomography (PET) to quantify β-amyloid (Aβ) plaques in the Tg2576 mouse …

The purpose of this study was to evaluate the feasibility of absolute quantification of regional
cerebral glucose utilization (rCMR glc ) in mice by use of 18 F-FDG and a small animal PET …

Objective Nicotinic acetylcholine receptors have close interactions with the dopaminergic
system and play critical roles in cognitive function. The purpose of this study was to compare …

The present study aims to image the 18-kDa translocator protein (TSPO; formerly known as
the peripheral benzodiazepine receptor) in a preclinical human breast cancer (BC) xenograft …

Pancreatic cancers are thought to be unusually hypoxic, which might sensitize them to drugs
that are activated under hypoxic conditions. In order to develop this idea in the clinic, a …

Patients with aneurysmal subarachnoid hemorrhage (SAH) frequently have deficits in
learning and memory that may or may not be associated with detectable brain lesions. We …

Quantitative small-animal PET of mice requires successful delivery of radiotracers into the
venous system. Intravenous injection of radiotracers via lateral tail veins is the most commonly …

Breast cancers (BCs) with high human epidermal growth factor receptor type 2 (HER2)
expression are most likely to respond to trastuzumab; however, the mechanisms of action of …