Aims Despite the effects of statins in reducing cardiovascular events and slowing progression
of coronary atherosclerosis, significant cardiovascular (CV) risk remains. Icosapent ethyl (…

Background Elevated coronary artery calcium (CAC) scores in subjects without prior
atherosclerotic cardiovascular disease (ASCVD) have been shown to be associated with increased …

Aims Though statin therapy is known to slow coronary atherosclerosis progression and
reduce cardiovascular (CV) events, significant CV risk still remains. In the REDUCE-IT study, …

Aims Icosapent ethyl (IPE) significantly reduced ischaemic events in statin-treated patients
with atherosclerosis or diabetes and elevated triglycerides in REDUCE-IT, including large …

… and Kinninger collected the patient information and generated the clinical data; Kinninger, …
Cherukuri, Birudaraju, Kinninger, Dr. Mao and Dr. Budoff drafted or revised the manuscript. …

2. Methods The study design and rationale for EVAPORATE and Garlic 5 have been published
previously. 2, 6 Eligible patients in EVAPORATE had known coronary atherosclerosis, …

Background Inflammation plays a key role and is one of the early steps in the pathogenesis
of endothelial function, thereby increasing the risk of hypertension (HTN), coronary artery …

Several previous studies have demonstrated that aged garlic extract (AGE) inhibits the
progression of coronary artery calcification and non‑calcified plaque (NCP) in the general …

Background Pericoronary adipose tissue (PCAT) attenuation has been identified as a marker
for cardiovascular risk. The effect of contrast enhancement on fat attenuation is unknown. …

Impaired endothelial function portends an increased risk of cardiovascular disease. Vascular
oxidative stress and systemic inflammation play a critical role in the pathogenesis and …