Skeletal PET with 18F-fluoride: applying new technology to an old tracer

FD Grant, FH Fahey, AB Packard… - Journal of nuclear …, 2008 - Soc Nuclear Med
Although 18 F-labeled NaF was the first widely used agent for skeletal scintigraphy, it
quickly fell into disuse after the introduction of 99m Tc-labeled bone-imaging agents. Recent …

Radioactive transition metals for imaging and therapy

E Boros, AB Packard - Chemical reviews, 2018 - ACS Publications
Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics

…, JLJ Dearling, N Veiga, AB Packard… - Nature …, 2021 - nature.com
The successful in vivo implementation of gene expression modulation strategies relies on
effective, non-immunogenic delivery vehicles. Lipid nanoparticles are one of the most …

[HTML][HTML] Intracoronary delivery of mitochondria to the ischemic heart for cardioprotection

…, I Friehs, Y Wu, S Levitsky, PJ Del Nido, AB Packard… - PloS one, 2016 - journals.plos.org
We have previously shown that transplantation of autologously derived, respiration-competent
mitochondria by direct injection into the heart following transient ischemia and reperfusion …

[HTML][HTML] Cyclotron production of 68Ga via the 68Zn (p, n) 68Ga reaction in aqueous solution

…, JF Byrne, H Jiang, AB Packard… - American journal of …, 2014 - ncbi.nlm.nih.gov
The objective of the present work is to extend the applicability of the solution target approach
to the production of 68 Ga using a low energy cyclotron. Since the developed method does …

Positron emission tomography (PET) imaging of neuroblastoma and melanoma with 64Cu-SarAr immunoconjugates

…, JS Huston, AB Packard - Proceedings of the …, 2007 - National Acad Sciences
The advancement of positron emission tomography (PET) depends on the development of
new radiotracers that will complement 18 F-FDG. Copper-64 ( 64 Cu) is a promising PET …

Imaging cancer using PET—the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody

…, JS Huston, CF Meares, ST Treves, AB Packard - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: Use of copper radioisotopes in antibody radiolabeling is challenged by
reported loss of the radionuclide from the bifunctional chelator used to label the protein. The …

Mitochondrial transplantation by intra-arterial injection for acute kidney injury

…, ER Snay, JA Inkster, AB Packard… - American Journal …, 2020 - journals.physiology.org
Acute kidney injury is a common clinical disorder and one of the major causes of morbidity
and mortality in the postoperative period. In this study, the safety and efficacy of autologous …

Mitochondrial transplantation enhances murine lung viability and recovery after ischemia-reperfusion injury

…, JAH Inkster, K Iken, AB Packard… - … of Physiology-Lung …, 2020 - journals.physiology.org
The most common cause of acute lung injury is ischemia-reperfusion injury (IRI), during
which mitochondrial damage occurs. We have previously demonstrated that mitochondrial …

Mitochondrial transplantation prolongs cold ischemia time in murine heart transplantation

…, D Zurakowski, DB Cowan, AB Packard… - The Journal of Heart and …, 2019 - Elsevier
BACKGROUND Cold ischemia time (CIT) causes ischemia‒reperfusion injury to the
mitochondria and detrimentally effects myocardial function and tissue viability. Mitochondrial …