User profiles for A.M. Zimmer

Alex Zimmer

University of New Brunswick
Verified email at unb.ca
Cited by 763

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

A Zimmer, AM Zimmer, AG Hohmann… - Proceedings of the …, 1999 - National Acad Sciences
Δ 9 -Tetrahydrocannabinol (Δ 9 -THC), the major psychoactive ingredient in preparations of
Cannabis sativa (marijuana, hashish), elicits central nervous system (CNS) responses, …

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

…, DR Compton, BR Martin, AM Zimmer… - Proceedings of the …, 1999 - National Acad Sciences
Cannabinoids, including the endogenous ligand arachidonyl ethanolamide (anandamide),
elicit not only neurobehavioral but also cardiovascular effects. Two cannabinoid receptors, …

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

M König, AM Zimmer, H Steiner, PV Holmes… - Nature, 1996 - nature.com
ENKEPHALINS are endogenous opioid peptides that are derived from a pre-proenkephalin
precursor protein 1,2 . They are thought to be vital in regulating many physiological functions…

Loss-of-function approaches in comparative physiology: is there a future for knockdown experiments in the era of genome editing?

AM Zimmer, YK Pan, T Chandrapalan… - Journal of …, 2019 - journals.biologists.com
Loss-of-function technologies, such as morpholino- and RNAi-mediated gene knockdown,
and TALEN- and CRISPR/Cas9-mediated gene knockout, are widely used to investigate …

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

…, L Wojnowski, AM Zimmer, J Hall, G Miller, A Zimmer - Nature medicine, 1998 - nature.com
Gorlin (or nevoid basal cell carcinoma) syndrome is characterized by a variety of clinical
problems including generalized overgrowth of the body, cysts, developmental abnormalities of …

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB1 Cannabinoid Receptor Knockout Mice: Evidence for Non‐CB1, Non‐CB2 Receptor …

…, RK Razdan, AM Zimmer, A Zimmer… - Journal of …, 2000 - Wiley Online Library
Anandamide [arachidonylethanolamide (AEA)] appears to be an endogenous agonist of brain
cannabinoid receptors (CB 1 ), yet some of the neurobehavioral effects of this compound …

Endothelial apoptosis in Braf-deficient mice

L Wojnowski, AM Zimmer, TW Beck, H Hahn, R Bernal… - Nature …, 1997 - nature.com
Tyrosine kinase growth factor receptors and Ras/Raf/MEK/MAPK signalling have been
implicated in the suppression 1–3 as well as augmentation of programmed cell death 4 . In …

Ammonia and urea handling by early life stages of fishes

AM Zimmer, PA Wright… - Journal of Experimental …, 2017 - journals.biologists.com
Nitrogen metabolism in fishes has been a focus of comparative physiologists for nearly a
century. In this Review, we focus specifically on early life stages of fishes, which have received …

[HTML][HTML] The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic …

…, A Markert, AM Zimmer, J Gertsch, A Zimmer - European …, 2014 - Elsevier
The widespread plant volatile beta-caryophyllene (BCP) was recently identified as a natural
selective agonist of the peripherally expressed cannabinoid receptor 2 (CB 2 ). It is found in …

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

…, A Gélot, A Cupo, A Zimmer, AM Zimmer… - Nature …, 2007 - nature.com
Psalmotoxin 1, a peptide extracted from the South American tarantula Psalmopoeus
cambridgei, has very potent analgesic properties against thermal, mechanical, chemical, …