Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 3
1979 1
1983 1
1985 1
1987 1
1989 1
1990 1
1991 1
1992 1
1993 1
1997 2
1998 1
1999 5
2000 2
2001 1
2002 2
2007 2
2008 3
2011 3
2012 1
2013 1
2014 1
2015 3
2016 6
2017 2
2018 1
2019 2
2020 1
2022 3
2023 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

50 results

Results by year

Filters applied: . Clear all
Page 1
Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation.
Gonzalez-Fierro C, Fonte C, Dufourd E, Cazaentre V, Aydin S, Engelhardt B, Caspi RR, Xu B, Martin-Blondel G, Spicer JA, Trapani JA, Bauer J, Liblau RS, Bost C. Gonzalez-Fierro C, et al. Among authors: spicer ja. Neurol Neuroimmunol Neuroinflamm. 2023 Apr 20;10(4):e200117. doi: 10.1212/NXI.0000000000200117. Print 2023 Jul. Neurol Neuroimmunol Neuroinflamm. 2023. PMID: 37080596 Free PMC article.
Fragment-based and structure-guided discovery of perforin inhibitors.
Jose J, Law RHP, Leung EWW, Wai DCC, Akhlaghi H, Chandrashekaran IR, Caradoc-Davies TT, Voskoboinik I, Feutrill J, Middlemiss D, Jeevarajah D, Bashtannyk-Puhalovich T, Giddens AC, Lee TW, Jamieson SMF, Trapani JA, Whisstock JC, Spicer JA, Norton RS. Jose J, et al. Among authors: spicer ja. Eur J Med Chem. 2023 Dec 5;261:115786. doi: 10.1016/j.ejmech.2023.115786. Epub 2023 Sep 1. Eur J Med Chem. 2023. PMID: 37716187 Free article.
Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.
Spicer JA, Miller CK, O'Connor PD, Jose J, Huttunen KM, Jaiswal JK, Denny WA, Akhlaghi H, Browne KA, Trapani JA. Spicer JA, et al. Eur J Med Chem. 2017 Sep 8;137:139-155. doi: 10.1016/j.ejmech.2017.05.048. Epub 2017 May 26. Eur J Med Chem. 2017. PMID: 28582670 Free PMC article.
Diarylthiophenes as inhibitors of the pore-forming protein perforin.
Miller CK, Huttunen KM, Denny WA, Jaiswal JK, Ciccone A, Browne KA, Trapani JA, Spicer JA. Miller CK, et al. Among authors: spicer ja. Bioorg Med Chem Lett. 2016 Jan 15;26(2):355-360. doi: 10.1016/j.bmcl.2015.12.003. Epub 2015 Dec 7. Bioorg Med Chem Lett. 2016. PMID: 26711151 Free PMC article.
Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors.
Gartlan KH, Jaiswal JK, Bull MR, Akhlaghi H, Sutton VR, Alexander KA, Chang K, Hill GR, Miller CK, O'Connor PD, Jose J, Trapani JA, Charman SA, Spicer JA, Jamieson SMF. Gartlan KH, et al. Among authors: spicer ja. ACS Pharmacol Transl Sci. 2022 May 31;5(6):429-439. doi: 10.1021/acsptsci.2c00009. eCollection 2022 Jun 10. ACS Pharmacol Transl Sci. 2022. PMID: 35711815 Free PMC article.
Benzenesulphonamide inhibitors of the cytolytic protein perforin.
Spicer JA, Miller CK, O'Connor PD, Jose J, Huttunen KM, Jaiswal JK, Denny WA, Akhlaghi H, Browne KA, Trapani JA. Spicer JA, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1050-1054. doi: 10.1016/j.bmcl.2016.12.057. Epub 2016 Dec 23. Bioorg Med Chem Lett. 2017. PMID: 28110869 Free PMC article.
Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.
Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W. Welz M, et al. Among authors: spicer ja. Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x. Nat Commun. 2018. PMID: 30442932 Free PMC article.
50 results