Technical Aspects and Administration Methods of 177Lu-DOTATATE for Nuclear Medicine Technologists

J Nucl Med Technol. 2019 Dec;47(4):288-291. doi: 10.2967/jnmt.118.221846. Epub 2019 Apr 24.

Abstract

At Banner M.D. Anderson Cancer Center in Arizona, we have gained valuable knowledge of the different infusion methods for 177Lu-DOTATATE peptide receptor radionuclide therapy. Methods: Our nuclear medicine department has used 2 different methods of administration: the gravity infusion method and the infusion pump protocol. Results: Our experience with the gravity infusion method allowed us to identify problematic aspects and led us to search for and implement the infusion pump protocol. Conclusion: The pump protocol ensures that the infusion of 177Lu-DOTATATE is safe and delivers a consistent dose to every patient.

Keywords: Lutathera; PRRT; gastroenteropancreatic neuroendocrine tumor; neuroendocrine cancer; pump protocol.

MeSH terms

  • Gravitation
  • Humans
  • Infusion Pumps
  • Nuclear Medicine / instrumentation*
  • Octreotide / administration & dosage
  • Octreotide / analogs & derivatives*
  • Octreotide / therapeutic use
  • Organometallic Compounds / administration & dosage*
  • Organometallic Compounds / therapeutic use

Substances

  • Organometallic Compounds
  • lutetium Lu 177 dotatate
  • Octreotide