90Y PET for Qualitative and Quantitative Assessment of Residual Activity in Delivery Apparatus After Radioembolization

J Nucl Med Technol. 2021 Jun;49(2):178-179. doi: 10.2967/jnmt.120.258251. Epub 2020 Dec 24.

Abstract

Assessment of residual activity is critical for quality assurance after 90Y radioembolization. The resin microsphere manufacturer's indirect method of estimating the residual activity is laborious and vulnerable to inaccuracies. Furthermore, the method cannot localize the exact site of residual activity. 90Y PET/CT for qualitative and quantitative assessment of residual activity has not, to our knowledge, been described. We show an example of 90Y PET/CT of residual activity in the delivery apparatus and catheters packed inside the delivery box. Focally intense residual activity was clearly localized to the stopcock junction. Residual activity was directly quantified by setting the PET volume-of-interest isocontour threshold to 1%.

Keywords: 90Y; PET/CT; SIR-Spheres; quantification; radioembolization; selective internal radiation therapy.

MeSH terms

  • Embolization, Therapeutic
  • Humans
  • Liver Neoplasms
  • Microspheres
  • Positron Emission Tomography Computed Tomography*
  • Radiopharmaceuticals
  • Yttrium Radioisotopes

Substances

  • Radiopharmaceuticals
  • Yttrium Radioisotopes