A 62-year-old patient with end-stage renal disease who is managed with continuous ambulatory peritoneal dialysis developed anterior abdominal wall swelling and pain that extended from just above peritoneal catheter site caudally. CT of the abdomen suggested pericatheter abscess with panniculitis. Tc-99m sulfur colloid peritoneal distribution planar scintigraphy suggested the diagnoses of pericatheter leak. The addition of SPECT/CT confirmed the latter diagnosis and pinpointed the exact location of the peritoneal leakage that was around insertion site. SPECT/CT was useful in establishing unequivocal diagnosis of peritoneal leak.