131I treatment of thyroid papillary carcinoma in a patient with renal failure

D W Morrish; L J Filipow; A J McEwan; R Schmidt; K R Murland; C von Westarp; K B Betcher

doi:10.1002/1097-0142(19901215)66:12<2509::aid-cncr2820661211>3.0.co;2-m

131I treatment of thyroid papillary carcinoma in a patient with renal failure

Cancer. 1990 Dec 15;66(12):2509-13. doi: 10.1002/1097-0142(19901215)66:12<2509::aid-cncr2820661211>3.0.co;2-m.

Authors

D W Morrish¹, L J Filipow, A J McEwan, R Schmidt, K R Murland, C von Westarp, K B Betcher

Affiliation

¹ Department of Medicine, University of Alberta, Edmonton, Canada.

Abstract

Procedures for 131I ablation in renal failure are not known. In one patient receiving dialysis, detailed dosimetry and health safety aspects were obtained. The results showed insignificant contamination of equipment, but a surprisingly significant reduction in biologic half-life of 131I due to efficient dialysis extraction. The data indicate that 131I ablation can be done safely and easily during dialysis but that much higher 131I doses must be used to achieve equivalent results to those obtained in patients with normal renal function.

Publication types

Case Reports

MeSH terms

Adult
Carcinoma, Papillary / complications
Carcinoma, Papillary / diagnostic imaging
Carcinoma, Papillary / radiotherapy*
Half-Life
Humans
Iodine Radioisotopes / administration & dosage
Iodine Radioisotopes / pharmacokinetics
Iodine Radioisotopes / therapeutic use*
Kidney Failure, Chronic / complications*
Kidney Failure, Chronic / metabolism
Male
Radionuclide Imaging
Radiotherapy Dosage
Renal Dialysis
Thyroid Gland / diagnostic imaging
Thyroid Neoplasms / complications
Thyroid Neoplasms / diagnostic imaging
Thyroid Neoplasms / radiotherapy*

Substances

Iodine Radioisotopes