Abstract
We assayed aqueous humor (AH) samples from patients with Behçet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated uveitis and control patients for the proinflammatory cytokines IL-15, IL-17, interferon-γ and tumor necrosis factor-α and the immunosuppressive cytokine IL-10. Cytokine levels were significantly higher in the three disease groups than in controls. In patients with similar disease activity, levels of IL-15 and IFN-γ were significantly higher in BD patients than in VKH and HLA-B27-associated uveitis groups. Logistic regression identified a significant negative correlation between BD and high levels of IL-10 and a significant positive correlation between VKH disease and high levels of IL-10. The proinflammatory cytokines versus IL-10 ratios were significantly higher in BD compared with other groups. These data suggest that both T helper (Th) 1 and Th17 cells are involved in endogenous uveitis immunopathogenesis. BD is characterized by extensive Th1 polarization, severe proinflammatory conditions and a low immunosuppressive status.
Copyright © 2010 Elsevier Inc. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adrenal Cortex Hormones / administration & dosage
-
Adrenal Cortex Hormones / pharmacology
-
Adrenal Cortex Hormones / therapeutic use
-
Adult
-
Aqueous Humor / drug effects
-
Aqueous Humor / metabolism*
-
Behcet Syndrome / diagnosis
-
Behcet Syndrome / drug therapy
-
Behcet Syndrome / immunology
-
Behcet Syndrome / metabolism
-
Cyclosporine / administration & dosage
-
Cyclosporine / pharmacology
-
Cyclosporine / therapeutic use
-
Cytokines / metabolism*
-
Female
-
HLA-B27 Antigen / genetics
-
Humans
-
Interferon-gamma / metabolism
-
Interleukin-10 / metabolism
-
Interleukin-15 / metabolism
-
Interleukin-17 / metabolism
-
Logistic Models
-
Male
-
Middle Aged
-
Th1 Cells / immunology
-
Th1 Cells / metabolism
-
Th17 Cells / immunology
-
Th17 Cells / metabolism
-
Treatment Outcome
-
Tumor Necrosis Factor-alpha / metabolism
-
Uveitis / diagnosis
-
Uveitis / drug therapy
-
Uveitis / genetics
-
Uveitis / immunology
-
Uveitis / metabolism*
-
Uveomeningoencephalitic Syndrome / diagnosis
-
Uveomeningoencephalitic Syndrome / immunology
-
Uveomeningoencephalitic Syndrome / metabolism
-
Young Adult
Substances
-
Adrenal Cortex Hormones
-
Cytokines
-
HLA-B27 Antigen
-
IL10 protein, human
-
Interleukin-15
-
Interleukin-17
-
Tumor Necrosis Factor-alpha
-
Interleukin-10
-
Interferon-gamma
-
Cyclosporine