Abstract
Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.
MeSH terms
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Aged
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Alzheimer Disease / diagnostic imaging
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Alzheimer Disease / physiopathology*
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Analysis of Variance
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Cerebrovascular Circulation / drug effects*
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Cerebrovascular Circulation / physiology
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Drug Evaluation
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Female
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Glycopyrrolate / administration & dosage
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Glycopyrrolate / pharmacology
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Humans
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Infusions, Intravenous
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Male
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Middle Aged
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Organotechnetium Compounds
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Oximes
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Parasympathetic Nervous System / drug effects*
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Parietal Lobe / blood supply
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Physostigmine / administration & dosage
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Physostigmine / antagonists & inhibitors
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Physostigmine / pharmacology*
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Technetium Tc 99m Exametazime
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Temporal Lobe / blood supply
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Tomography, Emission-Computed, Single-Photon / methods
Substances
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Organotechnetium Compounds
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Oximes
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Technetium Tc 99m Exametazime
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Physostigmine
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Glycopyrrolate