Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) and the role of reductant stabilisers

Richard M Fawdry

doi:10.1016/j.apradiso.2007.05.011

Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) and the role of reductant stabilisers

Appl Radiat Isot. 2007 Nov;65(11):1193-201. doi: 10.1016/j.apradiso.2007.05.011. Epub 2007 Jun 26.

Author

Richard M Fawdry¹

Affiliation

¹ PET & Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. rfawdry@nucmed.rpa.cs.nsw.gov.au

PMID: 17669662
DOI: 10.1016/j.apradiso.2007.05.011

Abstract

2-[18F]Fluoro-2-deoxy-D-glucose (FDG) is unstable at elevated temperatures, alkaline pH and in highly radioactive concentrated solutions. Radiolysis generates hydrogen peroxide in situ that accelerates the FDG decomposition rate and shortens the shelf life of the radiopharmaceutical. Reductant stabilisers slow down the decomposition rate and improve the shelf life for large-scale FDG manufacture in highly radioactive concentrated solutions.

MeSH terms

Drug Stability
Fluorodeoxyglucose F18 / chemistry*
Preservatives, Pharmaceutical
Radiochemistry*
Radiopharmaceuticals
Reducing Agents*

Substances

Preservatives, Pharmaceutical
Radiopharmaceuticals
Reducing Agents
Fluorodeoxyglucose F18