Abstract
Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-beta-D-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-beta-O-D-xyloside (5), and 25-anhydrocimigenol-beta-O-D-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1-3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actaea / chemistry*
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Animals
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal* / chemistry
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Drugs, Chinese Herbal* / isolation & purification
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Drugs, Chinese Herbal* / pharmacology
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Rhizome / chemistry
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Saponins* / chemistry
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Saponins* / isolation & purification
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Saponins* / pharmacology
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Triterpenes* / chemistry
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Triterpenes* / isolation & purification
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Triterpenes* / pharmacology
Substances
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25-O-ethylcimigenol-3-O-beta-D-xylopyranoside
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Saponins
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Triterpenes
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asiaticoside B
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cycloartane
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madecassoside
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asiaticoside