A new internal pair production branching ratio of 90Y: the development of a non-destructive assay for 90Y and 90Sr

R G Selwyn; R J Nickles; B R Thomadsen; L A DeWerd; J A Micka

doi:10.1016/j.apradiso.2006.08.009

A new internal pair production branching ratio of 90Y: the development of a non-destructive assay for 90Y and 90Sr

Appl Radiat Isot. 2007 Mar;65(3):318-27. doi: 10.1016/j.apradiso.2006.08.009. Epub 2006 Oct 11.

Authors

R G Selwyn¹, R J Nickles, B R Thomadsen, L A DeWerd, J A Micka

Affiliation

¹ Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 57306, USA. selwyn@wisc.edu <selwyn@wisc.edu>

PMID: 17045483
DOI: 10.1016/j.apradiso.2006.08.009

Abstract

(90)Y is utilized as a therapeutic radioisotope in radiolabeled monoclonal antibodies and in microspheres for targeted radiation therapy of the liver. Currently, the widely used dose calibrator assay of (90)Y can have uncertainties exceeding +/-10%. A non-destructive assay using spectroscopy is possible by reducing the currently published uncertainty (+/-12%) in the internal pair production branching ratio for the 0(+)-0(+) transition of (90)Zr. A high-purity germanium detector was used to determine the branching ratio to be (31.86+/-0.47) x 10(-6).

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Validation Study

MeSH terms

Calibration
Radiation Monitoring / methods*
Strontium Radioisotopes / analysis*
Yttrium Radioisotopes / analysis*

Substances

Strontium Radioisotopes
Yttrium Radioisotopes