Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)

Jan Marik; Julie L Sutcliffe

doi:10.1016/j.apradiso.2006.06.007

Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)

Appl Radiat Isot. 2007 Feb;65(2):199-203. doi: 10.1016/j.apradiso.2006.06.007. Epub 2006 Aug 28.

Authors

Jan Marik¹, Julie L Sutcliffe

Affiliation

¹ Department of Biomedical Engineering, University of California Davis, 451 East Health Sciences Drive, CA 95616-5294, USA.

PMID: 16935516
DOI: 10.1016/j.apradiso.2006.06.007

Abstract

The widely used bifunctional labeling reagent 4-[18F]fluorobenzoic acid ([18F]FBA) and its activated form N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77+/-5% (n=4) for [18F]FBA and 46+/-5% (n=4) for [18F]SFB. The presented synthetic procedure is highly reproducible and fully automated.

MeSH terms

Benzoates / chemical synthesis*
Fluorine Radioisotopes
Isotope Labeling
Radiopharmaceuticals / chemical synthesis*
Succinimides / chemical synthesis*

Substances

Benzoates
Fluorine Radioisotopes
Radiopharmaceuticals
Succinimides
N-succinimidyl-4-fluorobenzoate
4-fluorobenzoic acid