Abstract
Objective:
To compare high-performance liquid chromatography and SepPak as techniques for measuring the radiochemical purity of 99mTc-MAG3.
Methods:
Samples of 99mTc-MAG3 (n = 20) with radiochemical purities in the range 43-98% were prepared and analysed by both techniques.
Results:
The correlation between the results from the two techniques was excellent (r = 1.00) and the differences between the results were not statistically significant (P > 0.05).
Conclusion:
Both techniques are suitable for measuring the radiochemical purity of 99mTc-MAG3.
Publication types
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Comparative Study
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Evaluation Study
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Validation Study
MeSH terms
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Chemical Fractionation / methods*
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Chromatography, Agarose / methods*
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Chromatography, High Pressure Liquid / methods*
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Quality Assurance, Health Care / methods*
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Radiopharmaceuticals / chemical synthesis
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Radiopharmaceuticals / isolation & purification
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Reproducibility of Results
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Sensitivity and Specificity
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Technetium Tc 99m Mertiatide / chemistry*
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Technetium Tc 99m Mertiatide / isolation & purification*
Substances
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Radiopharmaceuticals
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Technetium Tc 99m Mertiatide