Abstract
A two-compartment model is used to derive the tissue time-activity curve of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG). At the later phase of the 18F-FDG activity in the tissue, the model leads to a method which allows the assessment of the 18F-FDG uptake rate constant. The proposed method is both compared with the standard uptake value (SUV) method and with Patlak's graphical analysis.
MeSH terms
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Algorithms*
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Animals
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Fluorodeoxyglucose F18 / pharmacokinetics*
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Humans
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Image Interpretation, Computer-Assisted / methods*
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Metabolic Clearance Rate
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Models, Biological*
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Neoplasms / diagnostic imaging*
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Neoplasms / metabolism*
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Positron-Emission Tomography / methods
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Radioisotope Dilution Technique
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Radiopharmaceuticals / pharmacokinetics
Substances
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Radiopharmaceuticals
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Fluorodeoxyglucose F18