Nuclear nephrourology continues to develop and expand on traditional provocative physiological maneuvers, such as diuretic and captopril renography. In addition, newer interventions are conceived, such as aspirin renography, which test new and fascinating aspects of renal functional reserve. Since the last review of this topic in 1991, nephrourologic nuclear medicine has made considerable progress in diverse ways. Captopril and diuresis renography have made strides in establishing greater consensus of interpretation and procedure. Commonplace aspirin, the ubiquitous wonder drug, has revealed an unexpected role in renography by way of its inhibition of prostaglandin E2. Finally, further investigations of exercise renography in essential hypertension have deepened the plausibility of a renal role in the etiology of perhaps 50% of affected individuals.