Chest
Clinical Investigations: CancerDynamic Positron Emission Tomography With F-18 Fluorodeoxyglucose Imaging in Differentiation of Benign From Malignant Lung/Mediastinal Lesions
Section snippets
MATERIALS AND METHODS
We studied 19 consecutive patients with an age range of 32 to 78 years referred for F-18 FDG PET studies for suspected malignant lesions in the lungs or in the mediastinum. These successive patients were studied as part of ongoing clinical studies at West Virginia University PET Center. All patients provided an informed consent for the PET studies. All patients fasted for at least 4 h prior to FDG injection. Serum glucose levels ranged from 80 to 160 mg/dL. These patients also had complete
RESULTS
The histologic specimens were obtained by needle biopsy (n = 10), thoracotomy (n = 8), or bronchoscopy (n = 1). Lesions ranged in size from 1 to 3.5 cm.
DISCUSSION
The high metabolism and increased rate of glucose consumption of cancer is associated with increased level of glycolytic enzymes and overexpression of glucose transporters as compared with the surrounding normal tissues.4, 10 It is well accepted that increased rates of transport and phosphorylation of the glucose analog and decreased rate of dephosphorylation of the phosphorylated sugars are important factors in the cellular mechanisms for tumor hypermetabolism.5, 6 Significant correlation has
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Short-duration dynamic FDG PET imaging: Optimization and clinical application
2020, Physica MedicaCitation Excerpt :Alternatively, dynamic PET imaging, employed mostly in the research setting, is able to track PET radiotracer biodistribution in the body over time, offering the possibility of further analysis including full kinetic modelling and potentially enhanced clinical tasks [4]. Some early studies have shown that dynamic quantitative measurements are superior to static acquisition in differentiating benign from malignant lung lesions specially in patients with borderline SUVs [5,6]. Furthermore, kinetic analysis can be particularly helpful in therapy response monitoring [7].
Biomedical Positron Emission Tomography (PET) imaging
2014, Biomedical Imaging: Applications and AdvancesResidual <sup>18</sup>F-FDG-PET uptake 12 weeks after stereotactic ablative radiotherapy for stage I non-small-cell lung cancer predicts local control
2012, International Journal of Radiation Oncology Biology PhysicsMolecular imaging for personalized cancer care
2012, Molecular Oncology
Presented as a scientific paper at Radiologic Society of North America meeting, December 1996