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Simultaneous Indocyanine Green and 99mTc-Antimony Sulfur Colloid-Guided Laparoscopic Sentinel Basin Dissection for Gastric Cancer

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

There are few reports on a dual dye and isotope approach using laparoscopy in gastric cancer sentinel node mapping. The aim of this study is to evaluate the feasibility of laparoscopic sentinel basin dissection for gastric cancer using simultaneous indocyanine green (ICG) and 99mTc-antimony sulfur colloid (ASC) injections.

Methods

Sixty-eight patients were enrolled who had been diagnosed with cT1–T2 and cN0 stage gastric cancers. They underwent laparoscopic sentinel basin dissection between June 2005 and May 2008. ICG and 99mTc-tin colloid (separate injections in the first phase, n = 16) or ICG and 99mTc-ASC (simultaneous injections in the second phase, n = 52) were injected into the submucosa endoscopically. After performing the sentinel basin dissection, laparoscopy-assisted gastrectomy with curative lymphadenectomy was done. Green-stained or radioactive sentinel nodes (SNs) were analyzed by hematoxylin and eosin staining and by immunohistochemistry for cytokeratin.

Results

SNs were identified in 62 of the 68 patients (91.2%; mean 3.3 per patient). Eighteen patients had lymph node metastases. The sensitivity and specificity were, respectively, 72.2 and 100% using the dye method and 83.3 and 100% by the isotope method. However, the dual dye/isotope procedure improved both sensitivity and specificity to 100%. Patients receiving this protocol had significantly more SNs than those receiving separate ICG and 99mTc-tin colloid injections (3.3 vs. 1.9, P = 0.008).

Conclusion

Simultaneous ICG and 99mTc-ASC-guided laparoscopic sentinel basin dissection is an effective tool for gastric cancer SN mapping, giving a high detection rate and excellent sensitivity.

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Acknowledgment

This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare, and Family Affairs, Republic of Korea (A085125).

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Authors and Affiliations

  1. Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea

    Do Joong Park MD, PhD & Hyung-Ho Kim MD, PhD

  2. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea

    Young Soo Park MD, PhD

  3. Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea

    Hye Seung Lee MD, PhD

  4. Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Korea

    Won Woo Lee MD, PhD

  5. Department of Surgery, Seoul National University Hospital, Seoul, Korea

    Hyuk-Joon Lee MD, PhD & Han-Kwang Yang MD, PhD

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  1. Do Joong Park MD, PhD
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  2. Hyung-Ho Kim MD, PhD
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  3. Young Soo Park MD, PhD
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  4. Hye Seung Lee MD, PhD
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  5. Won Woo Lee MD, PhD
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  6. Hyuk-Joon Lee MD, PhD
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  7. Han-Kwang Yang MD, PhD
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Corresponding author

Correspondence to Hyung-Ho Kim MD, PhD.

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Park, D.J., Kim, HH., Park, Y.S. et al. Simultaneous Indocyanine Green and 99mTc-Antimony Sulfur Colloid-Guided Laparoscopic Sentinel Basin Dissection for Gastric Cancer. Ann Surg Oncol 18, 160–165 (2011). https://doi.org/10.1245/s10434-010-1221-y

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  • DOI: https://doi.org/10.1245/s10434-010-1221-y

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