Multislice SPECT/CT in Benign and Malignant Bone Disease: When the Ordinary Turns Into the Extraordinary
Section snippets
Potential Applications in Patients With Cancer
The accurate detection or exclusion of bone metastases is of high clinical importance in the staging, management, and prognosis of cancer patients. The vertebral column and pelvis are the most common sites of metastatic bone disease due to the presence of a high proportion of red marrow.12 Furthermore, in the spine coexisting pathology, such as severe degenerative disease and compression fractures can make diagnosis of malignant infiltration or disease difficult.13
It is well recognized that
Potential Applications: Non-Oncology Scenario (Benign Bone Pathology)
Currently, there is limited evidence for the use of SPECT/CT in benign bone pathologies. Even-Sapir et al29 prospectively assessed the role of low-dose SPECT/CT (Infinia/Hawkeye 4) in 76 non-oncological patients with nonspecific findings on planar imaging. SPECT/CT reached a final diagnosis in 58% (49/85) of lesions in 59% (45/76) of patients, obviating the need to perform additional imaging.29 In addition, in another 30% (23/76) of patients, SPECT/CT guided additional imaging.
Conclusion
Hybrid imaging with SPECT/CT is not only a fascinating and exciting development but also challenging to optimize the combination of functional information and anatomical localization, which has the potential to influence medical practice with newer imaging algorithms. Most of the studies support the usefulness of SPECT/CT for improving diagnostic accuracy and increasing the confidence in interpreting the scans. However, published reports on the applications of SPECT/CT are still extremely
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Bone Metastasis in Prostate Cancer: Bone Scan Versus PET Imaging
2024, Seminars in Nuclear MedicineSPECT-CT in Foot and ankle surgery
2021, Fuss und SprunggelenkHybrid Bone SPECT/CT Imaging in Evaluation of Chronic Low Back Pain: Correlation with Facet Joint Arthropathy
2017, World NeurosurgeryCitation Excerpt :Thus, SPECT provides an objective, noninvasive, and functional test for FJ inflammation. The recent introduction of hybrid SPECT/CT imaging into clinical practice has been useful for anatomic and functional evaluation of benign and malignant spine bone diseases, particularly for evaluation of chronic low back pain.4,5,26-29 The use of CT for 3-dimensional anatomic localiation of disk and facet degenerative disease improves the diagnostic accuracy and the specificity of planar/SPECT bone scintigraphy.4,5,28
<sup>18</sup>F-NaF-PET/CT and <sup>99m</sup>Tc-MDP Bone Scintigraphy in the Detection of Bone Metastases in Prostate Cancer
2016, Seminars in Nuclear MedicineCitation Excerpt :Furthermore, it provides accurate information for detection or exclusion of metastatic bone disease in a single-section test that consequently accelerates diagnostic procedure and improves patient management.59 In addition, the fusion of SPECT and CT data has been shown to improve the diagnostic confidence of readers in differentiating malignant from benign bone lesions in cancerous diseases compared with SPECT alone or side-by-side reading of separate sets of scintigraphic and CT images.60,61 Nevertheless, precise evaluation of the pattern of tracer uptake as well as the use of SPECT allow for a proper interpretation in many cases.
Marble bone disease: The role of SPECT/CT hybrid imaging
2016, Archives de PediatriePitfalls and limitations of radionuclide planar and hybrid bone imaging
2015, Seminars in Nuclear MedicineCitation Excerpt :Subtle increase in tracer uptake which is not perceptible on a planar scintigraphy may be clearly visualized on SPECT/CT study (Fig. 31). In our experience, SPECT/CT has been useful in the assessment of the hip in cases of possible femoroacetabular impingement, insertional enthesopathies, bursitis, and avascular necrosis.58 MRI is commonly used for the initial imaging of the knee 99mTc-MDP bone SPECT/CT may have a complementary role in a subset of patients.