Clinical-alimentary tractContributions of gastric volumes and gastric emptying to meal size and postmeal symptoms in functional dyspepsia
Section snippets
Materials and methods
The protocol was approved by the Institutional Review Board of the Mayo Clinic. Investigators performing physiologic measurements (gastric volume by 99mTc-single-photon emission computed tomography [SPECT] imaging, gastric emptying by scintigraphy) were blinded regarding outcome measurements (maximum tolerated volume and postmeal symptoms assessed by the nutrient drink test).
Study population
During the study period, 57 patients with chronic upper gastrointestinal symptoms were enrolled. Of these, 39 met Rome II criteria for functional dyspepsia9 and the other 18 had other diagnoses (Figure 1). Twelve patients had undergone prior abdominal surgery or had underlying organic diseases associated with their gastrointestinal symptoms, and 6 met criteria for functional gastrointestinal disorders other than dyspepsia; all were excluded from the analysis.
Among the patients who were
Discussion
Our study has shown that, in patients with functional dyspepsia seen in a tertiary referral practice, food intake capacity is significantly dependent on body weight, gastric volume before the meal, and gastric emptying rate. We have also shown that symptoms after challenge are significantly influenced by age, body weight, size of the meal ingested, and gastric emptying rate. When integrated into a model, these factors explain up to 50% of the postprandial symptom scores postchallenge.
Symptoms
References (56)
- et al.
AGA technical reviewevaluation of dyspepsia
Gastroenterology
(1998) - et al.
Independent influences of body mass and gastric volumes on satiation in humans
Gastroenterology
(2004) - et al.
Assessment of functional gastrointestinal diseasethe bowel disease questionnaire
Mayo Clin Proc
(1990) - et al.
Noninvasive measurement of gastric accommodation in patients with idiopathic nonulcer dyspepsia
Am J Gastroenterol
(2001) - et al.
Role of impaired gastric accommodation to a meal in functional dyspepsia
Gastroenterology
(1998) - et al.
Impaired drinking capacity in patients with functional dyspepsiarelationship with proximal stomach function
Gastroenterology
(2001) - et al.
Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia
Am J Gastroenterol
(2003) - et al.
Noninvasive measurement of gastric accommodation in patients with idiopathic nonulcer dyspepsia
Am J Gastroenterol
(2001) - et al.
The proximal stomach and postprandial symptoms in functional dyspeptics
Am J Gastroenterol
(2002) - et al.
Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia
Gastroenterology
(1996)
Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia
Gastroenterology
Gastric electrical stimulation for medically refractory gastroparesis
Gastroenterology
Further experience with gastric stimulation to treat drug refractory gastroparesis
Am J Surg
The origin of symptoms on the brain-gut axis in functional dyspepsia
Gastroenterology
Long-term improvement in functional dyspepsia using hypnotherapy
Gastroenterology
A randomized controlled trial of psychotherapy in patients with chronic functional dyspepsia
Gastroenterology
An evidence-based approach to the management of uninvestigated dyspepsia in the era of Helicobacter pylori
CMAJ
Upper gastrointestinal symptoms in North Americaprevalence and relationship to healthcare utilization and quality of life
Dig Dis Sci
Content of family practicePart I. Rank order of diagnoses by frequency. Part II. Diagnoses by disease category and age/sex distribution
J Fam Pract
Social and economic effects of non-ulcer dyspepsia
Scand J Gastroenterol
Diet, food intake, and disturbed physiology in the pathogenesis of symptoms in functional dyspepsia
Am J Gastroenterol
Functional gastroduodenal disorders
Gut
Psychometric properties of the SUNYA revision of the Psychosomatic Symptom Checklist
J Behav Med
The Psychosomatic Symptom Checklist revisitedreliability and validity in a chronic pain population
J Behav Med
Development of a test to measure gastric accommodation in humans
Am J Physiol
Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans
Am J Physiol
SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication. Single photon emission computed tomography
Gut
Noninvasive measurement of gastric accommodation by means of pertechnetate SPECTlimiting radiation dose without losing image quality
J Nucl Med
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Supported in part by nursing support available through General Clinical Research Center grant RR00585 (Physiology Core) from the National Institutes of Health. M.C. is supported by grants DK54681, DK67071, and DK02638 from the National Institutes of Health. S.D.-A. was supported by the Falk Fellowship for Clinical Research Training at Mayo Foundation.