Original InvestigationTransplantationEffect of Clinical Variables and Immunosuppression on Serum Cystatin C and Beta-Trace Protein in Kidney Transplant Recipients
Section snippets
Study Population
Adult kidney transplant recipients followed up at the Ottawa Hospital, Ottawa, Canada, who were at least 6 months posttransplantation with stable kidney function (<20% change in serum creatinine level over the previous 2 measurements) were eligible to participate. Patients were excluded if they were pregnant or breast-feeding, unwilling or unable to provide consent, or likely to die of another comorbid disease or require dialysis therapy or retransplantation within the next 3 months or had
Demographics and Clinical Characteristics
Table 1 lists baseline characteristics of the study population (n = 207). The majority (92%) of patients were white, and only 2% were black. Sixty-four percent of patients were men, and average BMI was 28.2 ± 5.3 kg/m2. Patients had a wide range of kidney function that encompassed all 5 stages of the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) chronic kidney disease classification system.46 All except 3 patients were on prednisone therapy, and median daily
Discussion
This study characterized important associations between simple clinical parameters and levels of serum analytes used to estimate GFR in kidney transplant recipients. Women were found to have lower BTP, cystatin C, and serum creatinine concentrations; however, the magnitude of the difference was greatest for serum creatinine level. There was no effect of such commonly used immunosuppressive medications as prednisone, mycophenolate mofetil, cyclosporine, or tacrolimus. Age and race were not
Acknowledgements
We thank the staff and patients from the renal transplant program that participated in the study; the staff of the Nuclear Medicine Department at Ottawa Hospital for assistance with DTPA GFR measurements; and the coordinators at the Kidney Research Centre for invaluable assistance in conducting this study.
Support: This study was funded by The Physicians' Services Incorporated Foundation (Grant No. R03-59) and Astellas Pharma Canada. Instrumentation and reagents to measure cystatin C were
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2016, Kidney InternationalCitation Excerpt :We found that sex coefficients were significant in our development models, suggesting that the association between GFR and BTP differs by sex. BTP can also decrease with corticosteroids and its use may not be reliable in patients receiving these medications.29,30 B2M is a 11,600 Da protein that is a component of the major histocompatibility molecules present on all nucleated cells.15
Originally published online as doi: 10.1053/j.ajkd.2009.06.003 on July 21, 2009.
C.A.W. and A.A. contributed equally to this work.