Original articleAdenosine sestamibi SPECT post-infarction evaluation (INSPIRE) trial: A randomized, prospective multicenter trial evaluating the role of adenosine Tc-99m sestamibi SPECT for assessing risk and therapeutic outcomes in survivors of acute myocardial infarction☆
Section snippets
Methods
The organizational structure of the INSPIRE trial, including principal investigators and coinvestigators at participating centers and by-center recruitment, is contained in Appendix 1. A graphic representation of the INSPIRE study design is depicted in Figure 1. Over a 36-month period (December 1999 through December 2002), 728 patients were enrolled at 16 sites, with a 1-year subsequent follow-up.
Results
The results presented are limited to the baseline demographic, clinical, and scintigraphic characteristics of the 728 patients enrolled in the INSPIRE trial according to their risk group (Table 2) and the timing of adenosine SPECT imaging after hospital admission (Figure 3). The P values in Table 2 refer to a comparison across the four designated risk groups (ie, low, intermediate, high, and randomized).
The mean age across all groups was 63 years, with approximately one third of patients being
Discussion
The INSPIRE trial was designed to further define the potential role of quantitative adenosine Tc-99m sestamibi SPECT regarding two critical aspects of patient management after AMI: (1) risk stratification and (2) assessment of subsequent therapy. The INSPIRE study design included numerous features that were innovative and unique when compared with previous published trials.14, 33, 34
Acknowledgements
The authors have indicated they have no financial conflicts of interest.
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Supported by Bristol-Myers Squibb Medical Imaging, Fujisawa Healthcare, Inc, and Schering Plough Research Institute.