8Functional dyspepsia: drugs for new (and old) therapeutic targets
Section snippets
Acid secretion
Acid suppression is the most commonly prescribed empiric approach for the treatment of functional dyspepsia. The efficacy has been confirmed in meta-analyses6., 7. but the benefit does not have an unequivocal pathophysiologic explanation. In fact, gastric acid secretion is usually normal in subjects with functional dyspepsia8, and other mechanisms, such as hypersensitivity to normal acid concentration, impaired acid clearance from the duodenum or misdiagnosed gastroesophageal acid reflux may
Conclusions
Targeting relevant pathophysiological mechanisms is the most reasonable and widely pursued approach for drug development and testing in functional dyspepsia. However, only a proportion of the patients is likely to have a detectable abnormality of gastric physiology. Thus, targeting a single pathophysiologic pathway or a single abnormality may not provide complete improvement in most cases. The number and sophistication of treatment alternatives for functional dyspepsia will likely continue to
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Discovery and SAR of N-(1-((substituted piperidin-4-yl)methyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide derivatives: 5-Hydroxytryptamine receptor 4 agonist as a potent prokinetic agent
2016, European Journal of Medicinal ChemistryCitation Excerpt :Dyspepsia is defined as pain or discomfort in the upper abdomen [9]. In particular, functional dyspepsia is associated with abnormalities in gastric or duodenal physiology, including abnormal sensitivity to gastric acid, delayed gastric emptying, impaired gastric accommodation, and visceral hypersensitivity [9–11]. Prokinetic agents such as 5-HT4 agonists are potential therapeutic agents to treat GI tract disorders including functional dyspepsia (Fig. 1) [12,13].
Clinical practice guideline on the management of patients with dyspepsia. Update 2012
2012, Atencion PrimariaClinical practice guideline on the management of patients with dyspepsia. Update 2012
2012, Gastroenterologia y HepatologiaAdvancing gastric emptying studies: Standardization and new parameters to assess gastric motility and function
2012, Seminars in Nuclear MedicineCitation Excerpt :Because of the growing recognition of their potential clinical significance, it is important that we begin to include specific fundal and antral abnormal findings in our interpretation of GE studies. In the future, therapy may be directed specifically to these problems (Table 1).71 A simple visual approach is to look first for normal proximal fundal accommodation in the images (Fig. 2).
Gastrointestinal Scintigraphy
2007, Textbook of Gastrointestinal RadiologyCapsaicin: A Novel Approach to the Treatment of Functional Dyspepsia
2023, Molecular Nutrition and Food Research