The American Society of Breast SurgeonsScientific Impact Recognition Award: Molecular breast imaging: A review of the Mayo Clinic experience
Section snippets
MBI technology
In 2001, our first prototype MBI system was constructed. The system comprised a single, small, field-of-view semiconductor-based gamma camera (G.E. Medical Systems, Haifa, Israel) mounted on a modified mammography gantry. The detector, previously described in detail,17, 18, 19 was made up of an array of 80 × 80 cadmium zinc telluride (CZT) elements, each 2.5 × 2.5 mm, providing a 20 × 20 cm field of view. This CZT prototype offered improved energy resolution and spatial resolution relative to
Single-head prebiopsy study
Of the 100 women in the study, 53 patients had breast cancer confirmed at surgery, and 47 patients had benign findings. In the 53 patients with breast cancer, 59 tumors initially were identified with mammography and/or ultrasound and 8 additional tumors were identified with MBI, for a total of 67 tumors in the study. MBI detected 57 of the 67 tumors for a sensitivity of 85%. The average tumor size was 1.3 cm. Thirty-five tumors were 10 mm or less in diameter, of which 26 were detected on MBI
Comments
MBI has been studied in more than 900 patients at the Mayo Clinic during the past 6 years. In our experience, we have found the dedicated semiconductor-based MBI technology to offer optimal breast positioning analogous to mammography and superior spatial and energy resolution compared with conventional SMM cameras. From the body of work performed at the Mayo Clinic and at other laboratories23, 24, 25, 26, 27 it is clear that MBI has a potentially important role as an adjunct to mammography in
Acknowledgments
This work was supported by the National Institutes of Health and the Susan G. Komen Foundation.
The authors wish to thank Terry Brinkman, Peggy-Drews Radke, Barb Siem, Lori Johnson, Torey Alabin, Michelle Bartel, and Tracy Decklever for their assistance with this research.
References (32)
- et al.
The role of nuclear medicine in breast cancer detection: functional breast imaging
Radiol Clin North Am
(2001) - et al.
Molecular breast imaging: a new technique using technetium Tc 99m scintimammography to detect small tumors of the breast
Mayo Clin Proc
(2005) - et al.
Mammography with breast cushions
Womens Health Issues
(2005) - et al.
Neoadjuvant therapy in locally advanced breast cancer: 99mTc-MIBI mammoscintigraphy is not a reliable technique to predict therapy response
Breast
(2007) - et al.
Cancer statistics, 2008
CA Cancer J Clin
(2008) - et al.
Efficacy of screening mammography: a meta-analysis
JAMA
(1995) - et al.
Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality
Cancer
(2001) - et al.
Breast cancer screening: a summary of the evidence for the U.S. Preventive Services Task Force
Ann Intern Med
(2002) - et al.
Individual and combined effects of age, breast density, and hormone replacement therapy use on the accuracy of screening mammography
Ann Intern Med
(2003) - et al.
Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations
Radiology
(2002)