Renal clearance determination with one blood sample: Improved accuracy and universal applicability by a new calculation principle

doi:10.1016/S0001-2998(05)80064-9

Seminars in Nuclear Medicine

Volume 23, Issue 1, January 1993, Pages 73-86

https://doi.org/10.1016/S0001-2998(05)80064-9 Get rights and content

A sufficiently accurate quantification of renal function requiring only one plasma sample without an additional gamma camera study has until now only been possible in adults. A new principle has been developed that allows the universal application of known algorithms, irrespective of the clearance substance used, by normalizing the plasma concentrations with respect to individual body dimensions of adult as well as infant patients. In this respect, algorithms are established for clearance determinations using technetium-99m mercaptoacetyltriglycine which are based on steady-state studies as the reference. They allow the calculation of quantitative clearance values in infants and require the drawing of only one blood sample at any time between 25 and 40 minutes postinjection. The comparison with a combined-camera/two-plasma-sample technique performed in 46 children ranging in age from 9 days to 14 years (mean, 6.05 years) resulted in a standard deviation of 8.5% from the line of identity (r=0.94). Moreover, this procedure also increases accuracy in adult patients, especially those with impaired renal function.

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Renal clearance determination with one blood sample: Improved accuracy and universal applicability by a new calculation principle

Measurement of glomerular filtration rate: Single injection plasma clearance method without urine collection

J Nucl Med

Comparison of measurement of glomerular filtration rate by single sample, plasma disappearance slope/intercept and other methods

Eur J Med

Methods for measuring GFR with technetium-99m-DTPA: An analysis of several common methods

J Nucl Med

Determination of glomerular filtration rate by single-plasma sampling technique following injection of radioiodinated diatrizoate

J Nucl Med

Effective renal plasma flow: Estimation from theoretical volumes of distribution of intravenously injected 131 I-orthoiodohippurate

New formulas for the calculation of effective renal plasma flow

Eur J Nucl Med

Estimation of technetium-99m-MAG3 plasma clearance in adults from one or two blood samples

J Nucl Med

Technetium-99m-MAG3 für die nuklearmedizinische Nierenfunktionsdiagnostik

Volumes of distribution and clearances of intravenously injected creatinine in the dog

Am J Physiol

Measurements of renal function with radionuclides

J Nucl Med

Procedures of choice in renal nuclear medicine

J Nucl Med

Paediatric nuclear medicine

Eur J Nucl Med

Glomerular filtration rate in children: Where we have been: where we are going

J Nucl Med

Estimation of technetium-99m-MAG3 renal clearance in children: Two gamma camera techniques compared with multiple plasma samples

J Nucl Med

Estimation of effective renal plasma flow in children by use of a single plasma sample after injection of orthoiodohippurate

Single-sample method for the estimation of glomerular filtration rate in children

J Nucl Med

Estimation of glomerular filtration rate in infants and in children using a single-plasma sample method

J Nucl Med

Normalisation of glomerular filtration rate measurements

Eur J Med

The use of radiopharmaceuticals in the measurement of glomerular filtration rate: A review

Renal function studies using 99mTc-MAG3: Pharmacokinetics and slope clearance determination

Prediction of blood in normal human adults

Surgery

Erythrocyte volume, plasma volume, and lean body mass in adult men and women

Blood

Das Erythrocyten- und Plasmavolumen sowie die Relation zwischen Körperhämatokrit und venösem Hämatokrit in verschiedenen Stadien der essentiellen und bei renovasculärer Hypertonie

Klin Wschr

Estimated lean body mass as an index for normalization of body fluid volumes in humans

Am J Physiol

Comparison of methods for determination of glomerular filtration rate in renal disease

Scand J Clin Lab Invest

Estimation of technetium-99m-MAG₃ plasma clearance in adults from one or two blood samples

Technetium-99m-MAG₃ für die nuklearmedizinische Nierenfunktionsdiagnostik

Estimation of technetium-99m-MAG₃ renal clearance in children: Two gamma camera techniques compared with multiple plasma samples

Renal function studies using ^99mTc-MAG₃: Pharmacokinetics and slope clearance determination