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Positron emission tomography (PET) detectors with depth-of- interaction (DOI) capability

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Abstract

Because positron emission tomography (PET) provides biochemical information in vivo with the sensitivity at the sub-pico-molar level, pre-clinical research using PET plays an important role in biological and pharmaceutical sciences. However, small animal imaging by PET has been challenging with respect to spatial resolution and sensitivity due to the small volume of the imaging objects. A DOI-encoding technique allows for pre-clinical PET to simultaneously achieve high spatial resolution and high sensitivity. Thus many DOI-encoding methods have been proposed. In this paper we describe why DOI measurements are important, what is required in DOI-encoding designs, and how to extract DOI information in scintillator-based DOI detectors. Recently, there has been a growing interest in DOI measurements for TOF PET detectors to correct time walk as a function of DOI position. Thus, the DOI-encoding method with a high time performance suitable for TOF detectors is now required. The requirements to improve the time resolution in DOI detectors are discussed as well.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University College of Medicine, 28 Yungun-Dong, Chongno-Gu, Seoul, 110-744, Korea

    Mikiko Ito & Jae Sung Lee

  2. Department of Radiological Science, Eulji University, Gyeonggi-do, Korea

    Seong Jong Hong

  3. Departments of WCU Brain & Cognitive Sciences and Biomedical Sciences, Seoul National University, Seoul, Korea

    Jae Sung Lee

  4. Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea

    Mikiko Ito & Jae Sung Lee

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  1. Mikiko Ito
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Ito, M., Hong, S.J. & Lee, J.S. Positron emission tomography (PET) detectors with depth-of- interaction (DOI) capability. Biomed. Eng. Lett. 1, 70–81 (2011). https://doi.org/10.1007/s13534-011-0019-6

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