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PET kinetic analysis: error consideration of quantitative analysis in dynamic studies

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Abstract

Positron emission tomography dynamic studies have been performed to quantify several biomedical functions. In a quantitative analysis of these studies, kinetic parameters were estimated by mathematical methods, such as a nonlinear least-squares algorithm with compartmental model and graphical analysis. In this estimation, the uncertainty in the estimated kinetic parameters depends on the signal-to-noise ratio and quantitative analysis method. This review describes the reliability of parameter estimates for various analysis methods in reversible and irreversible models.

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Authors and Affiliations

  1. Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, 565-8565, Japan

    Yoko Ikoma & Hiroshi Watabe

  2. Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan

    Miho Shidahara, Mika Naganawa & Yuichi Kimura

  3. Japan Society for the Promotion of Science, Tokyo, Japan

    Mika Naganawa

Authors
  1. Yoko Ikoma
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  2. Hiroshi Watabe
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  3. Miho Shidahara
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  4. Mika Naganawa
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  5. Yuichi Kimura
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Correspondence to Yoko Ikoma.

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Ikoma, Y., Watabe, H., Shidahara, M. et al. PET kinetic analysis: error consideration of quantitative analysis in dynamic studies. Ann Nucl Med 22, 1–11 (2008). https://doi.org/10.1007/s12149-007-0083-2

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  • DOI: https://doi.org/10.1007/s12149-007-0083-2

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