Abstract
Statistical brain imaging analysis has good objectivity and reproducibility. In Japan, statistical parametric mapping (SPM) and three-dimensional stereotactic surface projections (3D-SSP) are used nationwide as statistical imaging analysis with standard brain coordinates. They often help to interpret brain single photon emission computed tomography (SPECT) images by avoiding possible pitfalls (e.g., effects of aging, atrophy) with which clinicians are unfamiliar. However, this type of analysis presents a problem: statistical processing requires many normal subject images. The easy Z-score imaging system (eZIS) is one of the statistical analysis methods that uses SPM processing in normalization and smoothing, and it has the function of image conversion leading to statistical analysis without a control database. Therefore, statistical analysis can be used in clinical practice by sharing a prepared normal database. By unifying the image quality by processing a shared database, this program has great potential for sharing patient imaging data in many hospitals. It is expected that the eZIS will help perform detailed analysis in many functional diseases in collaborative studies. This article describes the interpretation of brain SPECT images and suggests the usefulness and potential of eZIS.
Similar content being viewed by others
References
H Matsuda S Mizumura T Soma N Takemura (2004) ArticleTitleConversion of brain SPECT images between different collimators and reconstruction processes for analysis using statistical parametric mapping Nucl Med Commun 25 67–74 Occurrence Handle15061267 Occurrence Handle1:STN:280:DC%2BD2c7mslerug%3D%3D Occurrence Handle10.1097/00006231-200401000-00010
Matsuda H. Usefulness of new method of statistical image analysis in cerebral blood flow SPECT (easy Z-score imaging system; eZIS). Innervision 2000;97–103
D Kogure H Matsuda T Ohnishi T Asada M Uno T Kunihiro et al. (2000) ArticleTitleLongitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT J Nucl Med 41 1155–62 Occurrence Handle10914904 Occurrence Handle1:STN:280:DC%2BD3czpslemsA%3D%3D
K Ishii M Sasaki S Yamaji S Sakamoto H Kitagaki E Mori (1998) ArticleTitleRelatively preserved hippocampal glucose metabolism in mild Alzheimer's disease Dement Geriatr Cogn Disord 9 317–22 Occurrence Handle9769444 Occurrence Handle1:CAS:528:DyaK1cXnsFCitLc%3D Occurrence Handle10.1159/000017083
M Benoit PM Koulibaly O Migneco J Darcourt DJ Pringuey PH Robert (2002) ArticleTitleBrain perfusion in Alzheimer's disease with and without apathy: a SPECT study with statistical parametric mapping analysis Psychiatr Res 114 103–11
MC Petit-Taboue B Landeau JF Desson B Desgranges JC Baron (1998) ArticleTitleEffects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping Neuroimage 7 176–84 Occurrence Handle9597659 Occurrence Handle1:STN:280:DyaK1c3lvF2ntQ%3D%3D Occurrence Handle10.1006/nimg.1997.0318
M Signorini E Paulesu K Friston D Perani A Colleluori G Lucignani et al. (1999) ArticleTitleRapid assessment of regional cerebral metabolic abnormalities in single subjects with quantitative and nonquantitative [18F]FDG PET: a clinical validation of statistical parametric mapping Neuroimage 9 63–80 Occurrence Handle9918728 Occurrence Handle1:STN:280:DyaK1M7hvFGisg%3D%3D Occurrence Handle10.1006/nimg.1998.0381
KJ Friston J Ashburner JB Poline CD Frith JD Heather RS Frackowiak (1995) ArticleTitleSpatial registration and normalization of images Hum Brain Mapp 3 165–89 Occurrence Handle10.1002/hbm.460030303
KJ Friston CD Frith P Fletcher PF Liddle RS Frackowiak (1996) ArticleTitleFunctional topography: multidimensional scaling and functional connectivity in the brain Cereb Cortex 6 156–64 Occurrence Handle8670646 Occurrence Handle1:STN:280:BymB1cfmtFQ%3D
S Minoshima NL Foster DE Kuhl (1994) ArticleTitlePosterior cingulate cortex in Alzheimer's disease Lancet 344 895 Occurrence Handle7916431 Occurrence Handle1:STN:280:ByuA2snlslE%3D Occurrence Handle10.1016/S0140-6736(94)92871-1
S Minoshima KA Frey RA Koeppe NL Foster DE Kuhl (1995) ArticleTitleA diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET J Nucl Med 36 1238–48 Occurrence Handle7790950 Occurrence Handle1:STN:280:ByqA3M7gtlM%3D
T Ohnishi H Matsuda T Hashimoto T Kunihiro M Nishikawa T Uema et al. (2000) ArticleTitleAbnormal regional cerebral blood flow in childhood autism Brain 123 1838–44 Occurrence Handle10960047 Occurrence Handle10.1093/brain/123.9.1838
EJ Hoffman PD Cutler WM Digby JC Mazziotta (1990) ArticleTitleThree-dimensional phantom to simulate cerebral blood flow and metabolic images for PET IEEE Trans Nucl Sci 37 616–20 Occurrence Handle10.1109/23.106686
NJ Lobaugh CB Caldwell SE Black FS Leibovitch RH Swartz (2000) ArticleTitleThree brain SPET region-of-interest templates in elderly people: normative values, hemispheric asymmetries, and a comparison of single- and multihead cameras J Nucl Med 41 45–56 Occurrence Handle10647604 Occurrence Handle1:STN:280:DC%2BD3c7ht1Wgsg%3D%3D
MJ Ribeiro P Remy B Bendriem P Almeida V Brulon Y Samson et al. (2000) ArticleTitleComparison of clinical data sets acquired on different tomography using 6-18F-l-DOPA Eur J Nucl Med 27 707–12 Occurrence Handle10901458 Occurrence Handle1:STN:280:DC%2BD3M%2Fjt1entg%3D%3D Occurrence Handle10.1007/s002590050566
K Van Laere M Koole J Versijpt S Vandenberghe B Brans Y D'Asseler et al. (2001) ArticleTitleTransfer of normal 99mTc-ECD brain SPET databases between different gamma cameras Eur J Nucl Med 28 435–49 Occurrence Handle11357493 Occurrence Handle1:STN:280:DC%2BD38%2FgvFOlsw%3D%3D Occurrence Handle10.1007/s002590000461
R Takeuchi Y Yonekura H Matsuda J Konishi (2002) ArticleTitleUsefulness of a three-dimensional stereotactic ROI template on anatomically standardized 99mTc-ECD SPET Eur J Nucl Med 293 331–41 Occurrence Handle10.1007/s00259-001-0715-z
Y Otsuka S Tsuchikawa A Mitake N Takahashi C Kouno (2002) ArticleTitle[A case of transient global amnesia (TGA) showing bilateral hippocampal hypoperfusion by a new SPECT analyzing system, eZIS] (in Japanese) Rinsho Shinkeigaku 42 977–9 Occurrence Handle12739392
A Okumura Y Yasokawa N Nakayama K Miwa J Shinoda T Iwama (2005) ArticleTitle[The clinical utility of MR diffusion tensor imaging and spatially normalized PET to evaluate traumatic brain injury patients with memory and cognitive impairments] (in Japanese) No To Shinkei 57 115–22 Occurrence Handle15856757
H Watanabe H Sugihara M Horiuchi Y Takahashi (2005) ArticleTitle[Analysis of brain images in patients with spinocerebellar degeneration; using statistical parametric mapping (SPM) and easy Z score imaging system (eZIS)] (in Japanese) Kaku Igaku 42 107–13 Occurrence Handle16038429
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Mizumura, S., Kumita, Si. Stereotactic statistical imaging analysis of the brain using the easy Z-score imaging system for sharing a normal database. Radiat Med 24, 545–552 (2006). https://doi.org/10.1007/s11604-006-0056-8
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s11604-006-0056-8