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A Phase 2 Study of 16α-[18F]-fluoro-17β-estradiol Positron Emission Tomography (FES-PET) as a Marker of Hormone Sensitivity in Metastatic Breast Cancer (MBC)

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A Correction to this article was published on 15 October 2018

This article has been updated

Abstract

Purpose

16α-[18F]-fluoro-17β-estradiol positron emission tomography (FES-PET) quantifies estrogen receptor (ER) expression in tumors and may provide diagnostic benefit.

Procedures

Women with newly diagnosed metastatic breast cancer (MBC) from an ER-positive primary tumor were imaged before starting endocrine therapy. FES uptake was evaluated qualitatively and quantitatively, and associated with response and with ER expression.

Results

Nineteen patients underwent FES imaging. Fifteen had a biopsy of a metastasis and 15 were evaluable for response. Five patients had quantitatively low FES uptake, six had at least one site of qualitatively FES-negative disease. All patients with an ER-negative biopsy had both low uptake and at least one site of FES-negative disease. Of response-evaluable patients, 2/2 with low FES standard uptake value tumors had progressive disease within 6 months, as did 2/3 with qualitatively FES-negative tumors.

Conclusions

Low/absent FES uptake correlates with lack of ER expression. FES-positron emission tomography can help identify patients with endocrine resistant disease and safely measures ER in MBC.

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Change history

  • 15 October 2018

    Two data points from Table 1. (continued) were published in error. The corrected data in Table 1. (continued) are shown, in italic, below.

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Acknowledgements and Support

The authors would like to thank Eunice How, the radiochemistry staff, nuclear medicine technologists, and physicists in the UW Department of Radiology as well as the staff of the Fred Hutchinson Breast Cancer Research Center Cancer Biology lab. This study was sponsored by the NCI Phase I and II Cancer Imaging Program (Contract #N01-CM-37008, Protocol 8052) and was supported by the UPCI Biostatistics Shared Resource (P30CA047904).

Conflict of interest

None

Author information

Authors and Affiliations

  1. Radiology/Nuclear Medicine, University of Washington Medical Center–Seattle Cancer Care Alliance, Seattle, WA, USA

    Lanell M. Peterson, Erin K. Schubert & David A. Mankoff

  2. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Brenda F. Kurland, V.K. Gadi, Jennifer M. Specht, Peggy Porter & Hannah M. Linden

  3. Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA

    Brenda F. Kurland

  4. Radiology/Nuclear Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Erin K. Schubert & David A. Mankoff

  5. Radiology/Nuclear Medicine, University of Washington Medical Center, Seattle, WA, USA

    Jeanne M. Link & Janet F. Eary

  6. Medical Oncology, University of Washington Medical Center–Seattle Cancer Care Alliance, Seattle, WA, USA

    V.K. Gadi, Jennifer M. Specht & Hannah M. Linden

  7. Cancer Imaging Program, National Cancer Institute, Bethesda, MD, USA

    Lalitha K. Shankar

Authors
  1. Lanell M. Peterson
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  2. Brenda F. Kurland
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Correspondence to Lanell M. Peterson.

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Peterson, L.M., Kurland, B.F., Schubert, E.K. et al. A Phase 2 Study of 16α-[18F]-fluoro-17β-estradiol Positron Emission Tomography (FES-PET) as a Marker of Hormone Sensitivity in Metastatic Breast Cancer (MBC). Mol Imaging Biol 16, 431–440 (2014). https://doi.org/10.1007/s11307-013-0699-7

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