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Dynamic Changes of FDG Uptake and Clearance in Normal Tissues

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Abstract

Purpose

This study aims to evaluate dynamic 2-deoxy-2-[18F]fluoro-d-glucose (FDG) uptake in normal tissues.

Procedures

Thirty male patients underwent FDG positron emission tomography (PET)/computed tomography imaging at 1, 2, and 3 h after tracer injection. Standardized uptake values (SUV) were obtained in regions of interest of normal tissues.

Results

The aorta (blood pool), liver, and spleen FDG activity demonstrated significantly and continuously decreased activity from 1 to 2 and 2 to 3 h, while FDG uptake in the lungs, pancreas, lymph nodes, and skeletal muscle decreased from 1 to 2 h only. In contrast, the left ventricular myocardium demonstrated two patterns of dynamic changes: myocardium with higher FDG uptake (SUVmax ≥ 3.25) on the initial images had more remarkable increased activity on the delayed images, while myocardium with lower FDG uptake (SUVmax < 3.25) on the initial imaging had no increased uptake on delayed imaging. Increased FDG uptake was also observed in the bones on the delayed images. No significant changes of FDG uptake were noted in the parotid gland, thyroid gland, and prostate gland.

Conclusions

These findings may help nuclear medicine physicians when comparing images performed at different time points, when using FDG uptake in internal reference regions as a relative indicator of FDG uptake in a specific lesion, and when reading a delayed FDG PET imaging.

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Acknowledgments

This study was supported in part by a grant from the Department of Veterans Affairs (VISN 4 CPPF grant).

Conflict of Interest

None.

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Authors and Affiliations

  1. Department of Radiology, Philadelphia VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA, 19104, USA

    Gang Cheng, Esther Lim, Catherine V. Del Bello & Scott R Akers

  2. Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA

    Abass Alavi & Thomas J. Werner

Authors
  1. Gang Cheng
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  2. Abass Alavi
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  3. Esther Lim
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  4. Thomas J. Werner
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  5. Catherine V. Del Bello
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  6. Scott R Akers
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Corresponding authors

Correspondence to Gang Cheng or Scott R Akers.

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Cheng, G., Alavi, A., Lim, E. et al. Dynamic Changes of FDG Uptake and Clearance in Normal Tissues. Mol Imaging Biol 15, 345–352 (2013). https://doi.org/10.1007/s11307-012-0600-0

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  • DOI: https://doi.org/10.1007/s11307-012-0600-0

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