References
Lindell B (2004) Geschichte der Strahlenforschung. Teil 1: Pandoras Büchse. (in German) Universitätsverlag Aschenbeck und Isensee, Oldenburg
Cogan DG, Martin SF, Kimura SJ (1949) Atomic bomb cataracts. Science 110:654–655
Foley JH, Borges W, Yamawaki T (1952) Incidence of leukemia in survivors of the atomic bomb in Hiroshima and Nagasaki. Jpn Am J Med 13:311–321
Clarke R, Valentin J (2005) A history of the international commission on radiological protection. Health Phys 88:717–732
ICRP (1991) 1990 recommendations of the International Commission of Radiological Protection; ICRP Publication 60; Annals of the ICRP vol 21, pp 1–3
European Council Directive 96/29/Euratom
Kathren RL (1996) Pathway to a paradigm: the linear nonthreshold dose-response model in historical context. The American Academy of Health Physics 1995 Radiology Centennial Hartman Oration. Health Phys 70:621–635
Board on Radiation Effects Research (2005) BEIR VII: Health risks from exposure to low levels of ionizing radiation. Prepublication Copy. The National Academies Press, Washington DC
Brenner DJ, Doll R, Goodhead DT, Hall EJ, Land CE, Little JB, Lubin JH, Preston DL, Preston RJ, Puskin JS, Ron E, Sachs RK, Samet JM, Setlow RB, Zaider M (2003) Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proc Natl Acad Sci USA 100:13761–13766
Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C, Howe G, Kaldor J, Muirhead CR, Schubauer-Berigan M, Yoshimura T, Bermann F, Cowper G, Fix J, Hacker C et al. (2005) Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries. Br Med J 331:77. doi:10.1136/bmj.38499.599861.E0
Krestinina LY, Preston DL, Ostroumova EV, Degteva MO, Ron E, Vyushkova OV, Startsev NV, Kossenko MM, Akleyev AV (2005) Protracted radiation exposure and cancer mortality in the Techa River Cohort. Radiat Res 164:602–611
Kadhim MA, Moore SR, Goodwin EH (2004) Interrelationships amongst radiation-induced genomic instability, bystander effects, and the adaptive response. Mutat Res 568:21–32
Prise KM, Schettino G, Folkard M, Held KD (2005) New insights on cell death from radiation exposure. Lancet Oncol 6:520–528
Belyakov OV, Mitchell SA, Parikh D, Randers-Pehrson G, Marino SA, Amundson SA, Geard CR, Brenner DJ (2005) Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc Natl Acad Sci USA 102:14203–14208
Zhou H, Ivanov VN, Gillespie J, Geard CR, Amundson SA, Brenner DJ, Yu Z, Lieberman HB, Hei TK (2005) Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. Proc Natl Acad Sci USA 102:14641–14646
Marples B, Wouters BG, Collis SJ, Chalmers AJ, Joiner MC (2004) Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells. Radiation 161:247–255
Amundson SA, Lee RA, Koch-Paiz CA, Bittner ML, Meltzer P, Trent JM, Fornace AJ Jr (2003) Differential responses of stress genes to low dose-rate gamma irradiation. Mol Cancer Res 1:445–452
Coleman MA, Yin E, Peterson LE, Nelson D, Sorensen K, Tucker JD, Wyrobek AJ (2005) Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive response. Radiat Res 164:369–382
Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, Lee C, Cheng JF, Chen DJ (2005) Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat Res 164:17–26
Fujimori A, Okayasu R, Ishihara H, Yoshida S, Eguchi-Kasai K, Nojima K, Ebisawa S, Takahashi S (2005) Extremely low dose ionizing radiation up-regulates CXC chemokines in normal human fibroblasts. Cancer Res 65:10159–10163
Collis SJ, Schwaninger JM, Ntambi AJ, Keller TW, Nelson WG, Dillehay LE, Deweese TL (2004) Evasion of early cellular response mechanisms following low level radiation-induced DNA damage. J Biol Chem 279:49624–49632
Lavin MF, Birrell G, Chen P, Kozlov S, Scott S, Gueven N (2005) ATM signaling and genomic stability in response to DNA damage. Mutat Res 569:123–132
Rothkamm K, Löbrich M (2003) Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 100:5057–5062
Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A (2004) H2AX: the histone guardian of the genome. DNA Repair (Amst) 3:959–967
Antonelli F, Belli M, Cuttone G, Dini V, Esposito G, Simone G, Sorrentino E, Tabocchini MA (2005) Induction and repair of DNA double-strand breaks in human cells: dephosphorylation of histone H2AX and its inhibition by calyculin A. Radiat Res 164:514–517
Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J (2005) γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell 20:801–809
Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ (2005) A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery. Nature. doi:10.1038/nature04384
Aurengo A, Averbeck D, Bonnin A, Le Guen B, Masse R, Monier R, Tubiana M, Valleron AJ, de Vathaire F (2005) Dose-effect relationships and estimation of the carcinogenic effect of low doses of ionizing radiation. Académie des Sciences—Académie Nationale de Médecine, Paris
ICRP Committee 1 Task Group (2005) Low-dose extrapolation of radiation related cancer risk. http://www.icrp.org/draft_cancer.asp (20 Dec 2005)
Tubiana M, Aurengo A, Averbeck D, Masse R (2006) Recent reports on the effect of low doses of ionizing radiation and its dose-effect relationship. Radiat Environ Biophys 44. DOI 10.1007/s00411-006-0032-9
Brenner DJ, Sachs RK (2006) Estimating radiation-induced cancer risks at very low doses: rationale for using a linear no-threshold approach. Radiat Environ Biophys 44. DOI 10.1007/s00411-006-0029-4
Breckow J (2006) LNT is a radiation-protection standard rather than a mechanistic effect model. Radiat Environ Biophys 44. DOI 10.1007/s00411-006-0030-y
Kellerer AM (2002) Radiation risk–historical perspective and current issues. J Radiol Prot 22:A1–A10
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Friedl, A.A., Rühm, W. LNT: a never-ending story. Radiat Environ Biophys 44, 241–244 (2006). https://doi.org/10.1007/s00411-006-0028-5
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DOI: https://doi.org/10.1007/s00411-006-0028-5