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Recurrent pancreatic carcinoma and cholangiocarcinoma: 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT)

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Abstract

Although the current literature is limited, available data suggest that 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) imaging improves the evaluation of patients with recurrent pancreatic carcinoma and cholangiocarcinoma. There is evidence that PET/CT is particularly useful in the setting of elevated tumor markers and negative or equivocal CT findings. This article reviews the nature of these carcinomas in the post-therapy setting and describes the strengths and limitations of PET/CT when used for monitoring recurrence.

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References

  1. Jemal A, Siegel R, Ward E, et al. (2009) Cancer statistics, 2009. CA Cancer J Clin 59:225

    Article  PubMed  Google Scholar 

  2. American Gastroenterological Association medical position statement: epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. Gastroenterology 117:1463–1484 (1999)

    Google Scholar 

  3. West J, Wood H, Logan RF, Quinn M, Aithal GP (2006) Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971–2001. Br J Cancer 94(11):1751–1758

    Article  PubMed  CAS  Google Scholar 

  4. Khan SA, Taylor-Robinson SD, Toledano MB, Elliott Beck A, Thomas HC P (2002) Changing international trends in mortality rates for liver, biliary and pancreatic tumors. J Hepatol 37(6):806–813

    Article  PubMed  Google Scholar 

  5. Patel T (2002) Worldwide trends in mortality from biliary tract malignancies. BMC Cancer 3(2):10

    Article  Google Scholar 

  6. Nehls O, Gregor M, Klump B (2004) Serum and bile markers for cholangiocarcinoma. Semin Liver Dis 24(2):139–154

    Article  PubMed  CAS  Google Scholar 

  7. National Comprehensive Cancer Network (2008) Clinical practice guidelines in oncology, Hepatobiliary cancers. Version 2

  8. Huang QJ, Xu Q, Wang XN, et al. (2002) Spiral multi-phase CT in evaluating resectability of pancreatic carcinoma. Hepatobiliary Pancreat Dis Int 1(4):614–619

    PubMed  Google Scholar 

  9. Tamm EP, Loyer EM, Faria S, et al. (2006) Staging of pancreatic cancer with multidetector CT in the setting of preoperative chemoradiation therapy. Abdom Imaging 31(5):568–574

    Google Scholar 

  10. Diehl SJ, Lehmann KJ, Sadick M, et al. (1998) Pancreatic cancer: value of dual-phase helical CT in assessing resectability. Radiology 206:373–378

    PubMed  CAS  Google Scholar 

  11. McCarthy MJ, Evans J, Sagar G, et al. (1998) Prediction of resectability of pancreatic malignancy by computed tomography. Br J Surg 85:320–325

    Article  PubMed  CAS  Google Scholar 

  12. Ohtani T, Shirai Y, Tsukada K, et al. (1993) Carcinoma of the gallbladder: CT evaluation of lymphatic spread. Radiology 189:875–880

    PubMed  CAS  Google Scholar 

  13. Ward EM, Stephens DH, Sheedy PF (1983) Computed tomographic characteristics of pancreatic carcinoma: an analysis of 100 cases. Radiographics 3:547–565.

    Google Scholar 

  14. Solomon R (2009) Contrast-induced acute kidney injury (CIAKI). Radiol Clin North Am 47(5):783–788

    Article  PubMed  Google Scholar 

  15. Sperti C, Pasquali C, Bissoli S, et al. (2010) Tumor relapse after pancreatic cancer resection is detected earlier by 18-FDG PET than by CT. J Gastrointest Surg 14(1):131–140

    Article  PubMed  Google Scholar 

  16. Casneuf V, Delrue L, Kelles A, et al. (2007) Is combined 18F-flurodeoxyglucose-positron emission tomography/computed tomography superior to positron emission tomography or computed tomography alone for diagnosis, staging and restaging of pancreatic lesions? Acta Gastroenterol Belg 70(4):331–338

    PubMed  Google Scholar 

  17. Ruf J, Lopez Hanninen E, Oettle H, et al. (2005) Detection of recurrent pancreatic cancer: comparison of FDG-PET with CT/MRI. Pancreatology 5(2–3):266–272

    Article  PubMed  Google Scholar 

  18. Rose DM, Delbeke D, Beauchamp RD, et al. (1998) 18-Fluorodeoxyglucose-positron emission tomography (18FDG-PET) in the management of patients with suspected pancreatic cancer. Ann Surg 229:729–738

    Article  Google Scholar 

  19. Franke C, Klapdor R, Meyerhoff K, Schauman M (1999) 18-F Positron emission tomography of the pancreas: diagnostic benefit in the follow-up of pancreatic carcinoma. Anticancer Res 19:2437–2442

    PubMed  CAS  Google Scholar 

  20. Jadvar H, Fischman AJ (2001) Evaluation of pancreatic carcinoma with FDG PET. Abdom Imaging 26(3):254–259

    Article  PubMed  CAS  Google Scholar 

  21. Kim J, Quon A, Humke E, Ford JM, Koong AC (2009) Detection of solitary humeral metastasis from pancreatic adenocarcinoma with F-18 FDG PET/CT. Clin Nucl Med 34(5):312–313

    Article  PubMed  Google Scholar 

  22. Corvera CU, Blumgart LH, Akhurst T, et al. (2008) 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer. J Am Coll Surg 206:57–65

    Article  PubMed  Google Scholar 

  23. Jadvar H, Henderson RW, Conti PS (2007) (18F) fluorodeoxyglucose positron emission tomography and positron emission tomography: computed tomography in recurrent and metastatic cholangiocarcinoma. J Comput Assist Tomogr 31:223–228

    Article  PubMed  Google Scholar 

  24. Peters PE, Beyer K (1985) Normal lymph node cross-sections in different anatomic regions and their significance for computed tomographic diagnosis. Radiologe 25:193–198

    PubMed  CAS  Google Scholar 

  25. Dorfman RE, Alpern MB, Gross BH, Sandler MA (1991) Upper abdominal lymph nodes: criteria for normal size determined with CT. Radiology 180:319–322

    PubMed  CAS  Google Scholar 

  26. Lucey BC, Stuhlfaut JW, Soto JA (2005) Mesenteric lymph nodes: detection and significance on MDCT. Am J Roentgenol 184:41–44

    Google Scholar 

  27. Pansky B (1990) Anatomy of the pancreas. Emphasis on blood supply and lymphatic drainage. Int J Pancreatol. 7(1–3):101–108

    CAS  Google Scholar 

  28. Donatini B, Hidden G (1992) Routes of lymphatic drainage from the pancreas: a suggested segmentation. Surg Radiol Anat 14(1):35–42

    Article  PubMed  CAS  Google Scholar 

  29. Weber SM, Jarnagin WR, Klimstra D, et al. (2001) Intrahepatic cholangiocarcinoma: resectability, recurrence pattern, and outcomes. J Am Coll Surg 193(4):384–391

    Article  PubMed  CAS  Google Scholar 

  30. Yamamoto M, Takasaki K, Otsubo T, Katsuragawa H, Katagiri S (2001) Recurrence after surgical resection of intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg 8(2):154–157

    Article  PubMed  CAS  Google Scholar 

  31. Castaing D (2008) Surgical anatomy of the biliary tract. HPB 10:72–76

    Article  PubMed  Google Scholar 

  32. Diederichs CG, Staib L, Vogel J, et al. (2000) Values, limitations of 18F-fluorodeoxyglucose-positron-emission tomography with preoperative evaluation of patients with pancreatic masses. Pancreas 20:109

    Article  PubMed  CAS  Google Scholar 

  33. Shreve PD (1998) Focal fluorine-18 fluorodeoxyglucose accumulation in inflammatory pancreatic disease. Eur J Nucl Med 25:259–264

    Article  PubMed  CAS  Google Scholar 

  34. Diederichs CG, Staib L, Glasbrenner B, et al. (1999) F-18 Fluorodeoxyglucose (FDG) and C-reactive protein (CRP). Clin Pos Imaging 2:131–136

    Article  Google Scholar 

  35. Fritscher-Ravens A, Bohuslavizki KH, Broering DC, et al. (2001) FDG PET in the diagnosis of hilar cholangiocarcinoma. Nucl Med Commun 22:1277–1285

    Article  PubMed  CAS  Google Scholar 

  36. Kim YJ, Yun M, Lee WJ, Kim KS, Lee JD (2003) Usefulness of 18F-FDG PET in intrahepatic cholangiocarcinoma. Eur J Nucl Med Mol Imaging 30(11):1467–1472

    Article  PubMed  Google Scholar 

  37. Anderson CD, Rice MH, Pinson CW, et al. (2004) Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma. Gastrointest Surg 8(1):90–97

    Article  Google Scholar 

  38. Li TR, Tian JH, Wang H, Chen ZQ, Zhao CL F (2009) Pitfalls in positron emission tomography/computed tomography imaging: causes and their classifications. Chin Med Sci J 24(1):12–19

    Article  PubMed  Google Scholar 

  39. Zimny M, Bares R, Fass J, et al. (1997) Fluorine-18 fluorodeoxyglucose positron emission tomography in the differential diagnosis of pancreatic carcinoma: a report of 106 cases. Eur J Nucl Med 24:678–682

    PubMed  CAS  Google Scholar 

  40. Kostakoglu L, Hardoff R, Mirtcheva R, Goldsmith SJ (2004) PET-CT fusion imaging in differentiating physiologic from pathologic FDG uptake. Radiographics 24(5):1411–1431

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Mount Sinai Medical Center, 1 Gustave L. Levy Place, New York, NY, 10029, USA

    Katherine Cameron, Sivan Golan, William Simpson, Steven Peti, Sasan Roayaie, Daniel Labow & Lale Kostakoglu

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  1. Katherine Cameron
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  2. Sivan Golan
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  3. William Simpson
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  4. Steven Peti
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  5. Sasan Roayaie
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  6. Daniel Labow
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  7. Lale Kostakoglu
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Correspondence to Lale Kostakoglu.

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Cameron, K., Golan, S., Simpson, W. et al. Recurrent pancreatic carcinoma and cholangiocarcinoma: 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT). Abdom Imaging 36, 463–471 (2011). https://doi.org/10.1007/s00261-011-9729-6

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