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Is absolute quantification of dopaminergic neurotransmission studies with 123I SPECT ready for clinical use?

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References

  1. Laruelle M, Baldwin RM, Malison RT, Zea-Ponce Y, Zoghbi SS, al-Tikriti MS, et al. SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates. Synapse 1993;13:295–309.

    Article  PubMed  CAS  Google Scholar 

  2. Fischman AJ, Bonab AA, Babich JW, Palmer EP, Alpert NM, Elmaleh DR, et al. Rapid detection of Parkinson’s disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse 1998;29:128–41.

    Article  PubMed  CAS  Google Scholar 

  3. Abi-Dargham A, Gandelman MS, DeErausquin GA, Zea-Ponce Y, Zoghbi SS, Baldwin RM, et al. SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT. J Nucl Med 1996;37:1129–33.

    PubMed  CAS  Google Scholar 

  4. Schwarz J, Antonini A, Tatsch K, Kirsch CM, Oertel WH, Leenders KL. Comparison of 123I-IBZM SPECT and 11C-raclopride PET findings in patients with parkinsonism. Nucl Med Commun 1994;15:806–13.

    Article  PubMed  CAS  Google Scholar 

  5. Ichise M, Ballinger JR, Golan H, Vines D, Luong A, Tsai S, et al. Noninvasive quantification of dopamine D2 receptors with iodine-123-IBF SPECT. J Nucl Med 1996;37:513–20.

    PubMed  CAS  Google Scholar 

  6. Madsen MT. Recent advances in SPECT imaging. J Nucl Med 2007;48:661–73.

    Article  PubMed  Google Scholar 

  7. Wagenaar DJ, Kapusta M, Li J, Patt BE. Rationale for the combination of nuclear medicine with magnetic resonance for pre-clinical imaging. Technol Cancer Res Treat 2006;5:343–50.

    PubMed  Google Scholar 

  8. Crespo C, Gallego J, Cot A, Falcón C, Bullich S, Pareto D, et al. Quantification of dopaminergic neurotransmission SPECT studies with (123)I-labelled radioligands. A comparison between different imaging systems and data acquisition protocols using Monte Carlo simulation. Eur J Nucl Med Mol Imaging. 2008;in press. DOI 10.1007/s00259-007-0711-z.

  9. Zaidi H, Montandon M-L, Meikle S. Strategies for attenuation compensation in neurological PET studies. Neuroimage 2007;34:518–41.

    Article  PubMed  Google Scholar 

  10. El Fakhri G, Kijewski MF, Albert MS, Johnson KA, Moore SC. Quantitative SPECT leads to improved performance in discrimination tasks related to prodromal Alzheimer’s disease. J Nucl Med 2004;45:2026–31.

    PubMed  Google Scholar 

  11. Zaidi H, Koral KF. Scatter modelling and compensation in emission tomography. Eur J Nucl Med Mol Imaging 2004;31:761–82.

    Article  PubMed  Google Scholar 

  12. Koch W, Mustafa M, Zach C, Tatsch K. Influence of movement on FP-CIT SPECT quantification: a Monte Carlo based simulation. Nucl Med Commun 2007;28:603–14.

    Article  PubMed  Google Scholar 

  13. Shao L, Billings J, Pfeiffer N, Kung HF. Concentration recovery for SPECT CNS dopamine-receptor studies for monkeys. Med Phys 1994;21:675–81.

    Article  PubMed  CAS  Google Scholar 

  14. Soret M, Koulibaly PM, Darcourt J, Hapdey S, Buvat I. Quantitative accuracy of dopaminergic neurotransmission imaging with 123I SPECT. J Nucl Med 2003;44:1184–93.

    PubMed  CAS  Google Scholar 

  15. Cherry S, Sorenson JA, Phelps ME. Physics in nuclear medicine. 3rd ed. Philadelphia: Saunders; 2004.

    Google Scholar 

  16. Rowe RK, Aarsvold JN, Barrett HH, Chen JC, Klein WP, Moore BA, et al. A stationary hemispherical SPECT imager for three-dimensional brain imaging. J Nucl Med 1993;34:474–80.

    PubMed  CAS  Google Scholar 

  17. Genna S, Smith AP. The development of ASPECT, an annular single crystal brain camera for high efficiency SPECT. IEEE Trans Nucl Sci 1988;35:654–8.

    Article  CAS  Google Scholar 

  18. El Fakhri G, Ouyang J, Zimmerman RE, Fischman AJ, Kijewski MF. Performance of a novel collimator for high-sensitivity brain SPECT. Med Phys 2006;33:209–15.

    Article  PubMed  Google Scholar 

  19. Rogers WL, Clinthorne NH, Shao L, Chiao P, Ding Y, Stamos JA, et al. SPRINT II: a second generation single photon ring tomograph. IEEE Trans Med Imaging 1988;7:291–7.

    Article  PubMed  CAS  Google Scholar 

  20. Farncombe T, Celler A, Noll D, Maight J, Harrop R. Dynamic SPECT imaging using a single camera rotation (dSPECT). IEEE Trans Nucl Sci 1999;46:1055–61.

    Article  Google Scholar 

  21. Wong WH, Li H, Uribe J, Baghaei H, Wang Y, Yokoyama S. Feasibility of a high-speed gamma-camera design using the high-yield-pileup-event-recovery method. J Nucl Med 2001;42:624–32.

    PubMed  CAS  Google Scholar 

  22. Ljungberg M, Strand S-E, King MA. Monte Carlo calculations in nuclear medicine: applications in diagnostic imaging. Bristol: IOP Publishing; 1998.

    Google Scholar 

  23. Zaidi H. Relevance of accurate Monte Carlo modeling in nuclear medical imaging. Med Phys 1999;26:574–608.

    Article  PubMed  CAS  Google Scholar 

  24. Dewaraja YK, Ljungberg M, Koral KF. Monte Carlo evaluation of object shape effects in iodine-131 SPET tumor activity quantification. Eur J Nucl Med 2001;28:900–6.

    Article  PubMed  CAS  Google Scholar 

  25. Floyd CE, Jaszczak RJ, Greer KL, Coleman RE. Inverse Monte Carlo as a unified reconstruction algorithm for ECT. J Nucl Med 1986;27:1577–85.

    PubMed  Google Scholar 

  26. Beekman FJ, de Jong HW, van Geloven S. Efficient fully 3-D iterative SPECT reconstruction with Monte Carlo-based scatter compensation. IEEE Trans Med Imag 2002;21:867–77.

    Article  Google Scholar 

  27. Ouyang J, Fakhri GE, Moore SC. Fast Monte Carlo based joint iterative reconstruction for simultaneous [sup 99m]Tc/[sup 123]I SPECT imaging. Med Phys 2007;34:3263–72.

    Article  PubMed  CAS  Google Scholar 

  28. Wilson DW, Tsui BMW, Barrett HH. Noise properties of the EM algorithm. II. Monte Carlo simulations. Phys Med Biol 1994;39:847–71.

    Article  PubMed  CAS  Google Scholar 

  29. Zaidi H, Xu XG. Computational anthropomorphic models of the human anatomy: the path to realistic Monte Carlo modeling in medical imaging. Annu Rev Biomed Eng 2007;9:471–500.

    Article  PubMed  CAS  Google Scholar 

  30. Koch W, Hamann C, Radau PE, Tatsch K. Does combined imaging of the pre- and postsynaptic dopaminergic system increase the diagnostic accuracy in the differential diagnosis of parkinsonism? Eur J Nucl Med Mol Imaging 2007;34:1265–73.

    Article  PubMed  Google Scholar 

  31. Tossici-Bolt L, Hoffmann SMA, Kemp PM, Mehta RL, Fleming JS. Quantification of [123I]FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio. Eur J Nuc Med Mol Imaging 2006;33:1491–9.

    Article  Google Scholar 

  32. El Fakhri G, Moore SC, Maksud P, Aurengo A, Kijewski MF. Absolute activity quantitation in simultaneous 123I/99mTc brain SPECT. J Nucl Med 2001;42:300–8.

    PubMed  Google Scholar 

  33. Du Y, Tsui BMW, Frey EC. Model-based compensation for quantitative 123I brain SPECT imaging. Phys Med Biol 2006;51:1269–82.

    Article  PubMed  Google Scholar 

  34. Vanzi E, De Cristofaro M, Ramat S, Sotgia B, Mascalchi M, Formiconi A. A direct ROI quantification method for inherent PVE correction: accuracy assessment in striatal SPECT measurements. Eur J Nuc Med Mol Imaging 2007;34:1480–9.

    Article  Google Scholar 

  35. Koch W, Radau PE, Hamann C, Tatsch K. Clinical testing of an optimized software solution for an automated, observer-independent evaluation of dopamine transporter SPECT studies. J Nucl Med 2005;46:1109–18.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Nuclear Medicine, Geneva University Hospital, CH-1211, Geneva 4, Switzerland

    Habib Zaidi

  2. Nuclear Medicine and Molecular Imaging Division, Department of Radiology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, 02114, USA

    Georges El Fakhri

Authors
  1. Habib Zaidi
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  2. Georges El Fakhri
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Correspondence to Habib Zaidi.

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This Editorial Commentary refers to the article doi:10.1007/s00259-007-0711-z.

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Zaidi, H., El Fakhri, G. Is absolute quantification of dopaminergic neurotransmission studies with 123I SPECT ready for clinical use?. Eur J Nucl Med Mol Imaging 35, 1330–1333 (2008). https://doi.org/10.1007/s00259-008-0842-x

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  • DOI: https://doi.org/10.1007/s00259-008-0842-x

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