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Cardiac sympathetic neuronal imaging using PET

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Abstract

Introduction

Balance of the autonomic nervous system is essential for adequate cardiac performance, and alterations seem to play a key role in the development and progression of various cardiac diseases.

PET as an imaging tool

PET imaging of the cardiac autonomic nervous system has advanced extensively in recent years, and multiple pre- and postsynaptic tracers have been introduced. The high spatial and temporal resolution of PET enables noninvasive quantification of neurophysiologic processes at the tissue level. Ligands for catecholamine receptors, along with radiolabeled catecholamines and catecholamine analogs, have been applied to determine involvement of sympathetic dysinnervation at different stages of heart diseases such as ischemia, heart failure, and arrhythmia.

Review

This review summarizes the recent findings in neurocardiological PET imaging. Experimental studies with several radioligands and clinical findings in cardiac dysautonomias are discussed.

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Acknowledgements

Dr. Lautamäki is supported by a grant from the Finnish Medical Foundation, and by a Bracco/SNM Research Fellowship in Cardiovascular Molecular Imaging kindly provided by the Cardiovascular and Radiopharmaceutical Sciences Councils, the Society of Nuclear Medicine, and Bracco. Images shown in Figs. 1–3 were obtained during the tenure of Dr. Bengel at the Technical University of Munich, Germany.

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Authors and Affiliations

  1. Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA

    Riikka Lautamäki, Dnyanesh Tipre & Frank M. Bengel

  2. Cardiovascular Nuclear Medicine, 601 N Caroline St, JHOC 3225, Baltimore, MD, 21210, USA

    Frank M. Bengel

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  1. Riikka Lautamäki
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  2. Dnyanesh Tipre
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  3. Frank M. Bengel
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Correspondence to Frank M. Bengel.

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Lautamäki, R., Tipre, D. & Bengel, F.M. Cardiac sympathetic neuronal imaging using PET. Eur J Nucl Med Mol Imaging 34 (Suppl 1), 74–85 (2007). https://doi.org/10.1007/s00259-007-0442-1

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