Skip to main content

Advertisement

SpringerLink
Log in

Influence of collimator choice and simulated clinical conditions on 123I-MIBG heart/mediastinum ratios: a phantom study

  • Original Article
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

123I presents imaging problems owing to high-energy photon emission. We investigated the influence of collimators on 123I-MIBG heart/mediastinum ratios (H/M ratios). Secondly, we assessed the influence on H/M ratios of different activity concentrations, simulating clinical conditions. Thirdly, the value of scatter correction was assessed.

Methods

The AGATE cardiac phantom was filled with 123I in three sequential conditions: A, heart and mediastinal activity; B, adding lung activity; and C, adding liver activity (protocol I). In protocol II, myocardium and liver were filled with different activities ranging from low to high. For each condition, static anterior planar and single-photon emission computed tomography studies were acquired on a Siemens e.cam (SI) and a General Electric Millennium VG (GE) system, using low-energy high-resolution and medium-energy (ME) collimators for protocol I and only ME collimators for protocol II . For the SI camera, a triple energy window (TEW) scatter correction was applied.

Results

Planar H/M ratios were influenced by scatter and septal penetration from increasing amounts of liver activity. These effects were less pronounced for ME collimators. Although the TEW scatter correction increased ratios overall, TEW correction did not improve the relative differences between the ratios. TEW correction therefore does not add any benefit to obtain an accurate reflection of myocardial activity concentrations.

Conclusion

For straightforward implementation of semi-quantitative 123I-MIBG myocardial studies, we recommend the use of ME collimators without scatter correction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Merlet P, Valette H, Dubois-Rande JL, Moyse D, Duboc D, Dove P, et al. Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure. J Nucl Med 1992;33:471–7.

    CAS  PubMed  Google Scholar 

  2. Ogita H, Shimonagata T, Fukunami M, Kumagai K, Yamada T, Asano Y, et al. Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure: a prospective study. Heart 2001;86:656–60.

    Article  CAS  PubMed  Google Scholar 

  3. Patel AD, Iskandrian AE. MIBG imaging. J Nucl Cardiol 2002;9:75–94.

    Article  PubMed  Google Scholar 

  4. Somsen GA, van Vlies B, de Milliano PA, Borm JJ, van Royen EA, Endert E, et al. Increased myocardial [123I]-metaiodobenzylguanidine uptake after enalapril treatment in patients with chronic heart failure. Heart 1996;76:218–22.

    CAS  PubMed  Google Scholar 

  5. Takeishi Y, Atsumi H, Fujiwara S, Takahashi K, Tomoike H. ACE inhibition reduces cardiac iodine-123-MIBG release in heart failure. J Nucl Med 1997;38:1085–9.

    CAS  PubMed  Google Scholar 

  6. de Milliano PA, de Groot AC, Tijssen JG, Eck-Smit BL, Van Zwieten PA, Lie KI. Beneficial effects of metoprolol on myocardial sympathetic function: evidence from a randomized, placebo-controlled study in patients with congestive heart failure. Am Heart J 2002;144:E3.

    Article  PubMed  Google Scholar 

  7. Eichhorn EJ, McGhie AL, Bedotto JB, Corbett JR, Malloy CR, Hatfield BA, et al. Effects of bucindolol on neurohormonal activation in congestive heart failure. Am J Cardiol 1991;67:67–73.

    Article  CAS  PubMed  Google Scholar 

  8. Gerson MC, Craft LL, McGuire N, Suresh DP, Abraham WT, Wagoner LE. Carvedilol improves left ventricular function in heart failure patients with idiopathic dilated cardiomyopathy and a wide range of sympathetic nervous system function as measured by iodine 123 metaiodobenzylguanidine. J Nucl Cardiol 2002;9:608–15.

    Article  PubMed  Google Scholar 

  9. Yamazaki J, Muto H, Kabano T, Yamashina S, Nanjo S, Inoue A. Evaluation of beta-blocker therapy in patients with dilated cardiomyopathy—clinical meaning of iodine 123-metaiodobenzylguanidine myocardial single-photon emission computed tomography. Am Heart J 2001;141:645–52.

    Article  CAS  PubMed  Google Scholar 

  10. Kasama S, Toyama T, Kumakura H, Takayama Y, Ichikawa S, Suzuki T, et al. Spironolactone improves cardiac sympathetic nerve activity and symptoms in patients with congestive heart failure. J Nucl Med 2002;43:1279–85.

    CAS  PubMed  Google Scholar 

  11. Kasama S, Toyama T, Kumakura H, Takayama Y, Ichikawa S, Suzuki T, et al. Effect of spironolactone on cardiac sympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy. J Am Coll Cardiol 2003;41:574–81.

    Article  CAS  PubMed  Google Scholar 

  12. Somsen GA, Verberne HJ, Fleury E, Righetti A. Normal values and within-subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: implications for clinical studies. J Nucl Cardiol 2004;11:126–33.

    Article  PubMed  Google Scholar 

  13. Dobbeleir AA, Hambye AS, Franken PR. Influence of high-energy photons on the spectrum of iodine-123 with low- and medium-energy collimators: consequences for imaging with 123I-labelled compounds in clinical practice. Eur J Nucl Med 1999;26:655–8.

    Article  CAS  PubMed  Google Scholar 

  14. Inoue Y, Suzuki A, Shirouzu I, Machida T, Yoshizawa Y, Akita F, et al. Effect of collimator choice on quantitative assessment of cardiac iodine 123 MIBG uptake. J Nucl Cardiol 2003;10:623–32.

    Article  PubMed  Google Scholar 

  15. Ichihara T, Ogawa K, Motomura N, Kubo A, Hashimoto S. Compton scatter compensation using the triple-energy window method for single- and dual-isotope SPECT. J Nucl Med 1993;34:2216–21.

    CAS  PubMed  Google Scholar 

  16. Visser JJ, Sokole EB, Verberne HJ, Habraken JB, van de Stadt HJ, Jaspers JE, et al. A realistic 3-D gated cardiac phantom for quality control of gated myocardial perfusion SPET: the Amsterdam gated (AGATE) cardiac phantom. Eur J Nucl Med Mol Imaging 2004;31:222–8.

    PubMed  Google Scholar 

  17. Yamashina S, Yamazaki J. Role of MIBG myocardial scintigraphy in the assessment of heart failure: the need to establish evidence. Eur J Nucl Med Mol Imaging 2004;31:1353–5.

    Article  PubMed  Google Scholar 

  18. Buvat I, Benali H, Todd-Pokropek A, Di Paola R. Scatter correction in scintigraphy: the state of the art. Eur J Nucl Med 1994;21:675–94.

    Article  CAS  PubMed  Google Scholar 

  19. Takeda K, Saito K, Makino K, Saito Y, Aoki S, Koji T, et al. Iodine-123-BMIPP myocardial washout and cardiac work during exercise in normal and ischemic hearts. J Nucl Med 1997;38:559–63.

    CAS  PubMed  Google Scholar 

  20. Saito K, Takeda K, Okamoto S, Okamoto R, Makino K, Tameda Y, et al. Detection of doxorubicin cardiotoxicity by using iodine-123 BMIPP early dynamic SPECT: quantitative evaluation of early abnormality of fatty acid metabolism with the Rutland method. J Nucl Cardiol 2000;7:553–61.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Hein J. Verberne, Christel Feenstra, W. Matthijs de Jong, Berthe L. F. van Eck-Smit & Ellinor Busemann Sokole

  2. Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands

    G. Aernout Somsen

  3. Department of Nuclear Medicine, F2-238, Academic Medical Center, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands

    Hein J. Verberne

Authors
  1. Hein J. Verberne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christel Feenstra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Matthijs de Jong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Aernout Somsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Berthe L. F. van Eck-Smit
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ellinor Busemann Sokole
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hein J. Verberne.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Verberne, H.J., Feenstra, C., de Jong, W.M. et al. Influence of collimator choice and simulated clinical conditions on 123I-MIBG heart/mediastinum ratios: a phantom study. Eur J Nucl Med Mol Imaging 32, 1100–1107 (2005). https://doi.org/10.1007/s00259-005-1810-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-005-1810-3

Keywords

Search

Navigation