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Role of PET/CT in congenital histiocytosis

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Abstract

Congenital Langerhans cell histiocytosis (LCH) is a rare, but often severe, form of LCH. Although a more benign single-system congenital LCH has been described, most cases present as multisystem disease with poorer prognosis and are often treated with systemic chemotherapy. Imaging plays a central role in diagnosis, initial staging and assessment of treatment response. PET/CT is increasingly utilized for pediatric LCH. We report a unique case with PET/CT used as an imaging tool in staging and evaluating treatment response in congenital multisystem LCH.

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References

  1. Kaste SC, Rodriguez-Galindo C, McCarville ME et al (2007) PET-CT in pediatric Langerhans cell histiocytosis. Pediatr Radiol 37:615–622

    Article  PubMed  Google Scholar 

  2. Phillips M, Allen C, Gerson P et al (2009) Comparison of FDG-PET scans to conventional radiography and bone scans in management of Langerhans cell histiocytosis. Pediatr Blood Cancer 52:97–101

    Article  PubMed  Google Scholar 

  3. Writing Group of the Histiocyte Society (1987) Histiocytosis syndromes in children. Lancet 1:208–209

    Google Scholar 

  4. Minkov M, Prosch H, Steiner M et al (2005) Langerhans cell histiocytosis in neonates. Pediatr Blood Cancer 45:802–807

    Article  PubMed  CAS  Google Scholar 

  5. Dogan AS, Conway JJ, Miller JH et al (1996) Detection of bone lesions in Langerhans cell histiocytosis: complementary roles of scintigraphy and conventional radiography. J Pediatr Hematol Oncol 18:51–58

    Article  PubMed  CAS  Google Scholar 

  6. Binkovitz LA, Olshefski RS, Adler BH (2003) Coincidence FDG-PET in the evaluation of Langerhans' cell histiocytosis: preliminary findings. Pediatr Radiol 33:598–602

    Article  PubMed  Google Scholar 

  7. Krajicek BJ, Ryu JH, Hartman TE et al (2009) Abnormal fluorodeoxyglucose PET in pulmonary Langerhans cell histiocytosis. Chest 135:1542–1549

    Article  PubMed  Google Scholar 

  8. Brauner MW, Grenier P, Tijani K et al (1997) Pulmonary Langerhans cell histiocytosis: evolution of lesions on CT scans. Radiology 204:497–502

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA, 30322, USA

    Unni K. Udayasankar, Adina L. Alazraki & Stephen F. Simoneaux

  2. Department of Radiology, Children’s Healthcare of Atlanta at Egleston, Atlanta, GA, USA

    Adina L. Alazraki & Stephen F. Simoneaux

Authors
  1. Unni K. Udayasankar
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  2. Adina L. Alazraki
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  3. Stephen F. Simoneaux
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Correspondence to Unni K. Udayasankar.

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Udayasankar, U.K., Alazraki, A.L. & Simoneaux, S.F. Role of PET/CT in congenital histiocytosis. Pediatr Radiol 40 (Suppl 1), 57–61 (2010). https://doi.org/10.1007/s00247-010-1765-9

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  • DOI: https://doi.org/10.1007/s00247-010-1765-9

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