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PET-CT in pediatric Langerhans cell histiocytosis

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Abstract

Our objective was to assess the utility of PET-CT in five pediatric patients with Langerhans cell histiocytosis (LCH) who underwent PET-CT imaging for clinical staging and determination of lesion activity at various stages of treatment and follow-up. PET-CT combines the anatomic detail of CT and the physiologic activity of 18F-FDG imaging. We conclude that PET-CT information is clinically useful to evaluate disease activity and response to therapy and provides information that cannot be obtained from technetium 99m methylene diphosphonate bone scans or radiographs.

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Acknowledgements

This work was supported in part by grants P30 CA-21765 and P01 CA-20180 from the National Institutes of Health, a Center of Excellence grant from the state of Tennessee and the American Lebanese Syrian Associated Charities (ALSAC).

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Correspondence to Sue C. Kaste.

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Kaste, S.C., Rodriguez-Galindo, C., McCarville, M.E. et al. PET-CT in pediatric Langerhans cell histiocytosis. Pediatr Radiol 37, 615–622 (2007). https://doi.org/10.1007/s00247-007-0467-4

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  • DOI: https://doi.org/10.1007/s00247-007-0467-4

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