Skip to main content
Log in

Detection of complications after liver transplantation by technetium-99m mebrofenin hepatobiliary scintigraphy

  • Original Article
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Fifty-five hepatobiliary scintigraphic studies using99mTc-Mebrofenin were performed in 52 orthotopic liver transplant patients to evaluate suspected biliary complications, namely biliary extravasation and extrahepatic obstruction. Final diagnosis was made by analysis of the clinical course and other procedures.

Three out of three studies of biliary leak and four out of five studies of biliary obstruction were detected. There were no false positives in either complication. The sensitivity, specificity and accuracy were 100, 100, 100% for ectravasation and 80, 100, 98% for obstruction, respectively.

Hepatobiliary scintigraphy appears to be an accurate means of detecting biliary leak and obstruction associated with the transplanted liver.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Starzl TE, Demetris AJ: Liver transplantation: a 31-year perspective: part I.Curr Probl Surg 27: 55–116, 1990

    Article  Google Scholar 

  2. Starzl TE, Demetris AJ: Liver transplantation: a 31-year perspective: part II.Curr Probl Surg 27: 117–178, 1990

    PubMed  CAS  Google Scholar 

  3. Starzl TE, Demetris AJ: Liver transplantation: a 31-year perspective: part III.Curr Probl Surg 27: 181–240, 1990

    PubMed  CAS  Google Scholar 

  4. Iwatsuki S, Shaw BW Jr, Starzl TE: Biliary tract complications in liver transplantation under cyclosporin-steroid therapy.Transplant Proc 15: 1288–1291, 1983

    Google Scholar 

  5. Lerut J, Gordon RD, Iwatsuki S, et al: Biliary tract complications in human orthotopic liver transplantation.Transplantation 43: 47–51, 1987

    Article  PubMed  CAS  Google Scholar 

  6. Wilson BJ, Marsh JW, Makowka L, et al: Biliary tract complications in orthotopic adult liver transplantation.Am J Surgery 158: 68–70, 1989

    Article  CAS  Google Scholar 

  7. Stratta RJ, Wood RP, Langnas AN, et al: Diagnosis of biliary complications after liver transplantation.Surgery 106: 675–684, 1989

    PubMed  CAS  Google Scholar 

  8. Hawkins RA, Hall T, Gambhir SS, et al: Radionuclide evaluation of liver transplantation.Semin Nucl Med 18: 199–212, 1988

    Article  PubMed  CAS  Google Scholar 

  9. Krishnamurthy S, Krishnamurthy GT: Quantitative assessment of hepatobiliary diseases with Tc-99m-IDA scintigraphy.Nuclear Medicine Annual, New York, Raven Press, pp 309–330, 1988

    Google Scholar 

  10. Rosenthal L, Fonseca C, Arzourmanian A, et al:99mTc-IDA hepatobiliary imaging following upper abdominal surgery.Radiology 130: 735–739, 1979

    Google Scholar 

  11. Scott-Smith W, Raftery AT, Wraight EP, et al: Tc-99m labeled HIDA imaging in suspected biliary leaks after liver transplantation.Clin Nucl Med 10: 478–479, 1983

    Google Scholar 

  12. Loken MK, Ascher NL, Boudreau RJ, et al. Scintigraphic evaluation of liver transplant function.J Nucl Med 27: 451–459, 1986

    PubMed  CAS  Google Scholar 

  13. Von Mall LK, Juni JE, Merion RM: Scintigraphic demonstration of accessory hepatic duct leak following liver transplantation.J Nucl Med 29: 259–262, 1988

    Google Scholar 

  14. Klingensmith WC, Fritzberg AR, Spitzer VM, et al: Work in progress: clinical evaluation of Tc-99m-trimethylbromo-IDA and Tc-99m-Diisopropyl-IDA for hepatobiliary imaging.Radiology 146: 181–184, 1983.

    PubMed  Google Scholar 

  15. Liberman DA, Krishnamurthy GT: Intrahepatic versus extrahepatic cholestasis: discrimination with biliary scintigraphy combined with ultrasound.Gastroenterology 90: 734–43, 1986

    Google Scholar 

  16. Shah KK, Shah KK, Fink-Bennet D, et al: Extrahepatic biliary obstruction versus intrahepatic disorder: differentiation with hepatobiliary scintigraphy and ultrasonography.J Clin Gastroenterol 10: 191–196, 1988

    Article  PubMed  CAS  Google Scholar 

  17. Brown PH, Juni JE, Liberman DA, et al: Hepatocyte versus biliary disease: a discrimination by deconvolutional analysis of technetium-99m IDA time-activity curves.J Nucl Med 29: 623–630, 1988

    PubMed  CAS  Google Scholar 

  18. Itoh H, Takahashi N, Shimono R, et al: Assessment of hepatic excretory function in chronic liver disease by hepatobiliary scintigraphy.Ann Nucl Med 3: 139–142, 1989

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mochizuki, T., Tauxe, W.N., Dobkin, J. et al. Detection of complications after liver transplantation by technetium-99m mebrofenin hepatobiliary scintigraphy. Ann Nucl Med 5, 103–107 (1991). https://doi.org/10.1007/BF03164622

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03164622

Key words

Navigation