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Hepatoduodenal bile transit in cholecystectomized subjects

Relationship with sphincter of oddi function and diagnostic value

  • Pancreatic And Biliary Disorders
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Abstract

The hepatic hilum-duodenum transit time (HHDT) was evaluated in cholecystectomized subjects to assess its relationship with the motor function of the sphincter of Oddi (SO) and its diagnostic accuracy in the detection of SO dysfunction. The study was performed in asymptomatic controls and symptomatic patients with SO dysfunction before and after sphincterotomy. HHDT showed a direct correlation with manometric SO maximal basal pressure (r=0.77;P<0.001) but not with SO phasic activity. In sphincterotomized subjects HHDT did not differ from that of the asymptomatic subjects, and HHDT, which was prolonged before sphincterotomy, normalized after sphincterotomy. HHDT had a 100% specificity and an 83% sensitivity in diagnosing SO dysfunction when compared to SO manometry. In conclusion, the cholescintigraphic HHDT is mainly related to the SO maximal basal pressure, presenting an elevated specificity and a satisfactory sensitivity in the diagnosis of SO dysfunction in cholecystectomized subjects.

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References

  1. Torsoli A, Corazziari E, Habib FI, Cicala M: Pressure relationships within the human bile tract. Normal and abnormal physiology. Scand J Gastroenterol Suppl 175:52–57, 1990

    PubMed  Google Scholar 

  2. Pace RF, Chamberlain MJ, Passi RB: Diagnosing papillary stenosis by technetium 99m HIDA scanning. Can J Surg 26(2):191–193, 1983

    PubMed  Google Scholar 

  3. Zeman RK, Burrell MI, Dopbbins J, Jaffe MH, Choyke PL: Postcholecystectomy syndrome: Evaluation using biliary scintigraphy and endoscopic retrograde cholangiopancreatography. Radiology 156:787–792, 1985

    PubMed  Google Scholar 

  4. Shaffer EA, Hershfield NB, Logan K, Kloiber R: Cholescintigraphic detection of functional obstruction of the sphincter of Oddi. Effect of papillotomy. Gastroenterology 90:728–733, 1986

    PubMed  Google Scholar 

  5. Fullarton GM, Allan A, Hildtich T, Murray WR: Quantitative 99m Tc-DISIDA scanning and endoscopic biliary manometry in sphincter of Oddi dysfunction. Gut 29:1397–1401, 1988

    PubMed  Google Scholar 

  6. Darweesh RMA, Dodds WJ, Hogan WJ, Geenen JE, Collier BD, Shaker R, Kishk SMA, Stewart ET, Lawson TL, Hassanein EH, Joestgen TM: Efficacy of quantitative hepatobiliary scintigraphy and fatty meal sonography for evaluating patients with suspected partial common duct obstruction. Gastroenterology 94:779–786, 1988

    PubMed  Google Scholar 

  7. Lee RGL, Gregg JA, Koroshetz AM, Hill TC, Clouse ME: Sphincter of Oddi stenosis: Diagnosis using hepatobiliary scintigraphy and endoscopic manometry. Radiology 156:793–796, 1985

    PubMed  Google Scholar 

  8. Lieberman DA, Brown PH, Krishnamurthy GT: Improved scintigraphic assessment of severe cholestasis with the hepatic extraction fraction. Dig Dis Sci 35(11):1385–1390, 1990

    PubMed  Google Scholar 

  9. Sostre S, Kalloo AN, Spiegler EJ, Camargo EE, Wagner HN: A noninvasive test of sphincter of Oddi dysfunction in postcholecystectomy patients: The scintigraphic score. J Nucl Med 33:1216–1222, 1992

    PubMed  Google Scholar 

  10. Cicala M, Scopinaro F, Corazziari E, Vignoni A, Viscardi A, Habib FI, Torsoli A: Quantitative cholescintigraphy in the assessment of choledochoduodenal bile flow. Gastroenterology 100:1106–1113, 1991

    PubMed  Google Scholar 

  11. Fullarton GM, Hilditch T, Campbell A, Murray WR: Clinical and scintigraphic assessment of the role of endoscopic sphincterotomy in the treatment of sphincter of Oddi dysfunction. Gut 31:231–235, 1990

    PubMed  Google Scholar 

  12. Cicala M, Corazziari E, Habib FI, Scopinaro F, Piazzoni F, Schillaci O, Vignoni A, Ricci GL, Torsoli A: The scintigraphic measure of bile transit from the liver to the duodenum is not affected by liver disease. Gastroenterology 104(4):A357, 1993

    Google Scholar 

  13. Nardi GL, Acosta JM: Papillitis as a cause of pancreatitis and abdominal pain: Role of evocative test, operative pancreatography and histologic evaluation. Ann Surg 164:611–619, 1966

    PubMed  Google Scholar 

  14. O'Connor HJ, Bartlett RJ, Hamilton I, Ellis WR, Watters JK, Lintott DJ, Axon ATR: Bile duct calibre: The discrepancy between ultrasonic and retrograde cholangiographic measurement in the post-cholecystectomy patient. Clin Radiol 36:507–510, 1985

    PubMed  Google Scholar 

  15. Darweesh RM, Dodds WJ, Hogan WJ, Geenen JE, Lawson TL, Stewart ET, Shaker R, Kishk SM: Fatty-meal sonography for evaluating patients with suspected partial common duct obstruction. Am J Roentgenol 151(1):63–68, 1988

    Google Scholar 

  16. De Masi E, Corazziari E, Habib FI, Fontana B, Satti V, Fegiz G, Torsoli A: Manometric study of the sphincter of Oddi in patients with and without common bile duct stones and controls. Gut 25:275–278, 1984

    PubMed  Google Scholar 

  17. Toouli J, Roberts-Thomson IC, Dent J, Lee J: Manometric disorders in patients with suspected sphincter of Oddi dysfunction. Gastroenterology 88:1243–1250, 1985

    PubMed  Google Scholar 

  18. Corazziari E, Biliotti D, International Club for the Study of Oddi's Sphincter (ICSOS): Sphincter of Oddi manometry. Gastroenterol Int 2:180–184, 1989

    Google Scholar 

  19. Funch-Jensen P, Kruse A, Csendes A, Oster MJ, Andrup E: Biliary manometry in patients with post-cholecystectomy syndrome. Acta Chir Scand 148:267–268, 1982

    PubMed  Google Scholar 

  20. Sherman S, Troiano FP, Hawes RH, O'Connor KW, Lehman GA: Frequency of abnormal sphincter of Oddi manometry compared with the clinical suspicion of sphincter of Oddi dysfunction. Am J Gastroenterol 86(5):586–590, 1991

    PubMed  Google Scholar 

  21. Steinberg WM: Sphincter of Oddi dysfunction: A clinical controversy. Gastroenterology 95:1409–1415, 1988

    PubMed  Google Scholar 

  22. Habib FI: International workshop on sphincter of Oddi manometry. Data from questionnaires. Ital J Gastroenterol 18:35–36, 1986

    Google Scholar 

  23. Geenen JE, Hogan WJ, Dodds WJ, Toouli J, Venu RP: The efficacy of endoscopic sphincterotomy after cholecystectomy in patients with sphincter of Oddi dysfunction. N Engl J Med 320(2):82–87, 1989

    PubMed  Google Scholar 

  24. Neoptolemos JP, Bailey IS, Carr-Locke DL: Sphincter of Oddi dysfunction: results of treatment by endoscopic sphincterotomy. Br J Surg 75:454–459, 1988

    PubMed  Google Scholar 

  25. Thune A, Scicchitano J, Roberts-Thomson I, Toouli J: Reproducibility of endoscopic sphincter of Oddi manometry. Dig Dis Sci 36(10):1401–1405, 1991

    PubMed  Google Scholar 

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Corazziari, E., Cicala, M., Irene Habib, F. et al. Hepatoduodenal bile transit in cholecystectomized subjects. Digest Dis Sci 39, 1985–1993 (1994). https://doi.org/10.1007/BF02088136

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  • DOI: https://doi.org/10.1007/BF02088136

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