Abstract
Past measurement of gastric emptying of solid food in man has depended on external counting of surface-absorbed isotopes without verification that isotopic labels remain attached to solid food in the stomach. In this study chicken liver was isotopically labeled with99mTc incorporated uniformly and intracellularly throughout the liver substance.In vitro studies showed less than 10% loss of99mTc from liver incubated with pepsin HCl. By contrast, up to 90% of51Cr adsorbed to scrambled eggs became detached under similar conditions. In feeding experiments less than 10% of99mTc was liberated from fed99mTc liver, while significantly more51Cr became detached from egg under identical intragastric conditions. We conclude that99mTc-tagged chicken liver is an adequate marker of the rate of emptying of solid food and appears to be more reliable than51Cr-labeled scrambled eggs from which51Cr dissociates in the stomach.
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Griffith GH, Owen GM, Campbell H, Shields R: Gastric emptying in health and in gastroduodenal disease. Gastroenterology 54:1–7, 1968
Harvey RF, Mackie DB, Brown NJG, Keeling DH, Davies WT: Measurement of gastric emptying time with a gamma camera. Lancet 1:16–18, 1970
Van Dam APM: The gamma camera in clinical evaluation of gastric emptying. Radiology 110:155–157, 1974
Heading RC, Tothill P, Laidlaw AJ, Shearman DJC: An evaluation of113mIndium DTPA chelate in the measurement of gastric emptying by scintiscanning. Gut 12:611–615, 1971
Horner PU: In: Radioactive Pharmaceuticals, U.S.A.E.C. Div. of Technical Information, Oakridge, Tennessee, 1966, pp 335–358
MacGregor IL, Gueller R, Watts HD, Meyer JH: The effect of acute hyperglycemia on gastric emptying in man. Gastroenterology 70:190–196, 1976
MacGregor IL, Deveney CD, Meyer JH: The effect of acute hyperglycemia on meal stimulated gastric, biliary, and pancreatic secretion, and serum gastrin. Gastroenterology 70:197–202, 1976
MacKenzie RD, Anwar RA, Byerrum RU: Absorption and distribution of51Cr in the albino rat. Arch Biochem Biophys 79:200–205, 1959
Hunt JN, Knox MT: Regulation of gastric emptying. Handbook of Physiology, Sect. 6 Alimentary Canal, Vol. 4, CF Code (ed). Washington, DC, American Physiology Society, 1968, Chap. 94, pp 1917–1935
George JD: New clinical method for measuring the rate of gastric emptying: the double sampling test meal. Gut 9:237–242, 1968
Dozois RR, Kelly KA, Code CF: Effect of distal antrectomy on gastric emptying of liquids and solids. Gastroenterology 61:675–681, 1971
Heading RC, Tothill P, McLoughlin GP, Shearman DJC: Gastric emptying rate measured in man: a method for simultaneous study of solid and liquid phases. Gut 15:841, 1974 (abstract)
Thomas JE: Mechanics and regulation of gastric emptying. Physiol Rev 37:453–474, 1957
Carlson HC, Code CF, Nelson RA: Motor action of the canine gastroduodenal junction: A cineradiographic, pressure, electric study. Am J Dig Dis 11:155–172, 1966
Forth W, Rummel W: Iron absorption. Physiol Rev 63:724–792, 1973
Avioli LV: Intestinal absorption of calcium. Arch Intern Med 129:345–355, 1972
Herbert V: Absorption of vitamin B12 and folic acid. Gastroenterology 54:110–115, 1968
Toskes PP, Deren JJ: Vitamin B12 absorption and malabsorption. Gastroenterology 65:662–683, 1973
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This study was supported by research funds from the Veterans Administration and N.I.H. Grant R01 AM18014-01. Studies in human subjects were performed with informed consent under approval by the Human Experimentation Committee of the University of California, San Francisco, California (Protocol 228705).
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Meyer, J.H., MacGregor, I.L., Gueller, R. et al. 99mTc-Tagged chicken liver as a marker of solid food in the human stomach. Digest Dis Sci 21, 296–304 (1976). https://doi.org/10.1007/BF01071842
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DOI: https://doi.org/10.1007/BF01071842