Abstract
Infection imaging has been challenging over the past four decades, which provided an excellent playing field for researchers working in this area, and till date the quest continues to find an ideal imaging agent. Labelled leukocytes were first developed in the 1970s for imaging infection lesions such as osteomyelitis, cellulitis, diabetic foot, Crohn’s disease, inflammatory bowel disease, fever of unknown origin, etc. Subsequently labelled antibiotics such as 99mTc-labelled ciprofloxacin have emerged for directly identifying live bacterial infections. From the early 1970s through the mid-1980s, 67Ga-Citrate was the prime radionuclide for imaging of inflammation and infection of musculoskeletal origin. Although 68Ga-PET was described in 1960s for tumour imaging, recent reports described 68Ga-Citrate and 68Ga-transferrin as possible agents for PET-imaging of infection due to successful application of 67Ga-Citrate SPECT in the past, despite its limitations. It is important to establish a faster imaging method for 68Ga, as its half-life is 68 min compared to 78.3 hrs for 67Ga. Preparation of 68Ga-Citrate and 68Ga-transferrin is described, with very high yield and high radiochemical purity (RCP), which is ideally suited for routine clinical studies. Biodistribution of 68Ga-Citrate-PET images were characterised with high blood pool, high liver and bone (growth plate) uptake with low soft-tissue activity. 68Ga-Citrate or 68Ga-transferrin was able to detect infected lesions in rats within 5–10 min post injection but a focal intense uptake at the lesion (SUVmax) was visualized only at 30 min, which increased for up to 6 hrs post injection with concomitant decrease in the cardiac blood pool activity. The liver and bowel activity decreased after 90 min then stabilised. In the patient studies, infection lesions were detected within 30 min post injection of 68Ga-Citrate. Cardiac blood pool and liver activities decreased during the period of study. Interestingly, there was persistent high vascular activity in the thigh region. One of the major limitations of 67Ga-Citrate SPECT is the delayed post injection waiting time of 48 hrs, in contrast to 60 min post injection waiting with 68Ga-Citrate. The distinct difference in imaging time is intriguing, although there is no chemical difference between 67Ga-Citrate and 68Ga-Citrate, except for the radiolabel. No literature is available on early imaging times using 67Ga-SPECT. When compared 68Ga/67Ga-Citrate images at 60 min post injection in normal rats, 68Ga-PET showed better images with low background activity than 67Ga-SPECT agent. This may be due to short half-life of 68Ga (68 min), as it would have decayed one half-life at 60 min post-imaging time, compared to the SPECT agent (67Ga), which would require 76 hrs to undergo one half-life. Therefore, the visual difference in background can be attributed to the difference in the half-lives of these two agents. Similarly, uptake of 68Ga by liver, cardiac blood pool activity is much lower than 67Ga at 60 min post injection period, may be attributed to the faster decay of 68Ga than 67Ga. High background activity of 68Ga-Citrate in the thorax and upper abdomen at 60 min post-injection may interfere with detecting lesions in these regions; therefore, 68Ga-PET is more suitable for imaging lesions in the lower abdomen and the extremities. The short half-life of 68Ga (68 min) may be advantageous from low dosimetry to the patients, but disadvantageous for longer periods of study. Since 68Ga-Citrate was capable of detecting infection within 60 min, the need for imaging for longer periods may not be warranted. The functional imaging was not limited to diagnosing infection but it could be extended to surgical planning and antibiotic therapy monitoring of osteomyelitis and in distinguishing prosthetic infection from loosening of prosthesis. 18F-FDG is sensitive but has the limitation of giving false positive results in patients with bone prosthesis, even if there is no infection or mobilisation. But the available literature clearly indicated 68Ga-Citrate was positive only in cases of infection. In summary, preliminary reports suggest 68Ga-Citrate PET/CT is useful in the diagnosis of suspected bone infections with reliable sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy. Preliminary reports with 68Ga-Transferrin showed it is capable of detecting both Gram-positive Staphylococcus aureus (Staph A) and Gram-negative Proteus mirobilis. This is an incidental finding but gives an insight into the potential of this agent to detect more than one bacterial infection.
Keywords
- Positron Emission Tomography
- Positron Emission Tomography Imaging
- Stable Zinc Isotope
- Imaging Infection
- Positron Emission Tomography Agent
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Aardaneh K, van der Walt K (2006) Ga2O for target, solvent extraction for radiochemical separation and SnO2 for the preparation of a 68Ge/68Ga generator. J Radioanal Nucl Chem 268:25–32
Aisen P, Listowsky I (1980) Iron transport and storage proteins. Annu Rev Biochem 49:357–393
Akhtar MS, Qaisar A, Irfanullah J et al (2005) Antimicrobial peptide 99mTc-ubiquicidin 29–41 as human infectionimaging agent: clinical trial. J Nucl Med 46:567–573
Allan RA, Sladen GE, Bassingham S et al (1993) Comparison of simultaneous 99mTc-HMPAO and 111In oxine labelled white cell scans in the assessment of inflammatory bowel disease. Eur J Nucl Med 20:195–200
Antunes P, Ginj M, Zhang H et al (2007) Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals. Eur J Nucl Med Mol Imaging 34:982–993
Arseneau JC, Aamodt R, Johnston GS et al (1974) Evidence for granutocytic incorporation of 67gallium in chronic granulocytic leukemia. J Lab Clin Med 83:496–503
Asti S et al (2008) Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC. Nucl Med Biol 35:721–724
Barron B, Hanna C, Passalaqua AM, Lamki L, Wegener WA, Goldenberg DM (1999) Rapid diagnostic imaging of acute, nonclassic appendicitis by leukoscintigraphy with sulesomab, a technetium 99 m-labeled antigranulocyte antibody Fab’ fragment. LeukoScan Appendicitis Clinical Trial Group. Surgery 125:288–296
Bailey S, Evans RW, Garratt RC et al (1988) Molecular structure of serum transferrin at 3.3 Å resolution. Biochemistry 27:5804–5812
Baum RP, Prasad V, Hommann M et al (2008) Receptor PET/CT imaging of neuroendocrine tumors. Recent Results Cancer Res 170:225–242
Baum RP, Prasad V et al (2010) Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In- or 68Ga-labeled affibody molecules. J Nucl Med 51(6):892–897
Bernstein L (1998) Mechanisms of therapeutic activity for Gallium. Pharmacol Rev 50:665–682
Becker W, Repp R, Hansen HJ et al (1995) Binding characteristics and kinetics of a new Tc-99 m-antigranulocyte Fab’ fragment (Leukoscan TM). J Nucl Med 36(Suppl):208P
Bitran J, Bekerman C, Weinstein R et al (1987) Patterns of gallium-67 scintigraphy in patients with acquired immunodeficiency syndrome and the AIDS related complex. J Nucl Med 28:1103–1106
Boerman OC, Dams ETM, Oyen WJG, Corstens FHM, Storm G (2001) Radiopharmaceuticals for scintigraphic imaging of infection and inflammations. Inflamm Res 50:55–64
Bombardieri E, Aktolun C, Baum RP, Bishof-Delaloye A, Buscombe J, Chatal JF (2003) 67Ga scintigraphy: procedure guidelines for tumor imaging. Eur J Nucl Med Mol Imaging 30:BP125–BP131
Breeman WAP, de Jong M, de Blois E et al (2004) Radiolabelling DOTA-peptides with 68Ga. Eur J Nucl Med 32:478–485
Burleson R, Johnson M, Head H (1973) Scintigraphic demonstration of experimental abscesses with intravenous 67Ga-citrate and 67Ga labeled blood leukocytes. Ann Surg 178:446–451
Burleson RL, Johnson MC, Head H (1974) In vitro and in vivo labeling of rabbit blood leukocytes with 67Ga-citrate. J Nucl Med 15:98–101
Chianelli M, Mather SJ, Martin-Comin J, Signore A (1997) Radiopharmaceuticals for the study of inflammatory processes: a review. Nucl Med Commun 18:437–455
Conry BG, Papathanasiou ND, Prakash V et al (2010) Comparison of 68Ga-DOTATATE and 18F-fluorodeoxyglucose PET/CT in the detection of recurrent medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging 37:49–57
Coleman RE (2000) FDG imaging. Nucl Med Biol 27(7):689–690
de Winter F, Vogelaers D, Gemmel F, Dierckx RA (2002) Promising role of 18F-fluoro-D-deoxyglucose positron emission tomography in clinical infectious diseases. Eur J Clin Microbiol Infect Dis 21:247–257
Dimitrakopoulou-Strauss A, Hohenberger P, Haberkorn U, Macke HR, Eisenhut M (2007) 68Ga-labeled bombesin studies in patients with gastrointestinal stromal tumours: comparison with 18F-FDG. J Nucl Med 48:1245–1250
Edwards CL, Hayes RL (1969) Tumor scanning with 67Ga-citrate. J Nucl Med 10:103–105
Ehrhardt GJ, Welch MJ (1978) A new germanium-68/gallium-68 generator. J Nucl Med 19:925–929
Einhorn TA (1998) The cell and molecular biology of fracture healing. Clin Orthop 355S:7–21
El-Maghraby TA, Moustafa HM, Pauwels EK (2006) Nuclear medicine methods for evaluation of skeletal infection among other diagnostic modalities. Q J Nucl Med Mol Imaging 50:167–192
Gabriel M, Decristoforo C, Kendler D et al (2007) 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med 48:508–518
Gelrud LG, Arseneau JC, Milder MS et al (1974) The kinetic of 67-gallium incorporation into inflammatory lesions: experimental and clinical studies. J Lab Clin Med 85:489–495
Gravius S, Gebhard M, Ackermann D et al (2010) Analysis of 18F-FDG uptake pattern in PET for diagnosis of aseptic loosening versus prosthesis infection after total knee arthroplasty: a prospective pilot study. Nuklearmedizin 49:115–123
Harris DC, Aisen P (1989) In: Loehr TM et al (ed) Iron carriers and iron proteins. VCH, Weinheim, pp 239–351
Henkin RE (1978) Gallium-67 in the diagnosis of inflammatory disease. In: Hoffer PB, Bekerman C, Henkin RE (eds) Gallium-67 imaging. Wiley, New York, pp 65–92
Henze M, Schuhmacher J, Hipp P et al (2001) PET imaging of somatostatin receptors using 68Ga-DOTA-D-Phel-Tyr3-octreotide: first results in patients with meningiomas. J Nucl Med 42:1053–1056
Hofmann M, Ma¨cke HR, Bo¨rner AR et al (2001) Biokinetics and imaging with the somatostatin receptor PET radioligand 68Ga-DOTA TOC: preliminary data. Eur J Nucl Med 28:1751–1757
Hopkins GB, Mende CW (1975) Gallium-67 and subphrenic abscesses—is delayed scintigraphy necessary? J Nucl Med 16:609–611
Hoffer P (1980) Gallium: mechanisms. J Nucl Med 21:282–285
Hughes DK (2003) Nuclear medicine and infection detection: the relative effectiveness of imaging with 111In-oxine–, 99mTc-HMPAO–, and 99mTc-stannous fluoride colloid-labeled leukocytes and with 67Ga-citrate. J Nucl Med Technol 31:196–201
Huebers HA, Finch CA (1987) The physiology of transferrin and transferring receptors. Physiol Rev 67:520–582
Ichiya Y, Kuwabara Y, Sasaki M et al (1996) FDG-PET in infectious lesions: the detection and assessment of lesion activity. Ann Nucl Med 10:185–191
Iqbal MS, Khan J, Irfanullah MA et al (2004) 99mTc-labeled antimicrobial peptide ubiquicidin (29–41) accumulates less in Escherichia coli infection than in Staphlococcus aureus infection. J Nucl Med 45:849–856
Ito Y, Okuyama S, Awano T, Takahashi K, Sato T (1971) Diagnostic evaluation of Ga-67 scanning of lung cancer and other diseases. Radiology 101:355–362
Jeong JM, Hong MK, Chang YS et al (2008) Preparation of a promising angiogenesis PET imaging agent: 68Ga-labeled c(RGDyK)-isothiocyanatobenzyl-1,4,7-triaza-cyclononane-1,4,7-triacetic acid and feasibility studies in mice. J Nucl Med 49(5):830–836
Kelly MJ, Kalff V, Hicks RJ et al (1990) 111In-oxine labelled leukocyte scintigraphy in the detection and localization of active inflammation and sepsis. Med J Aust 152:352–357
Kopecky P, Mudrová B, Svoboda K (1973) The study of conditions for the preparation and utilization of 68Ge–68Ga generator. Int J Appl Radiat Isot 24:73–80
Kopecky P, Mudrová B (1974) 68Ge–68Ga generator for the production of 68Ga in an ionic form. Int J Appl Radiat Isot 25:263–268
Koort JK, Mäkinen TJ, Knuuti J, Jalava J, Aro HT (2004) Comparative 18F-FDG-PET imaging of experimental Staphylococcus aureus osteomyelitis and normal bone healing. J Nucl Med 45:1406–1411
Kramer EL, Sanger JH, Garay SM et al (1989) Diagnostic implications of Ga-67 chest scan patterns in human immunodeficiency virus-seropositive patients. Radiology 170:671–676
Kumar V (2005) Radiolabeled white blood cells and direct targeting of micro-organisms for infection imaging. Q J Nucl Med Mol Imaging 49:325–338
Kumar V, Ali M, Angelides S et al (2007) Synthesis and characterisation of 99mTc-glucosamine and 99mTc-His-CP and evaluation of their utility in imaging inflammatory arthritis. J ANZ Nucl Med 38(3):10–13
Kumar V, Boddeti DK, Evans SG, Roesch F, Howman-Giles R (2009) Is 68Ga-citrate a novel agent for PET-imaging of Staphylococcus aureus infection? Eur J Nucl Med Mol Imaging 36(Suppl 2):S194–S233
Kumar V, Boddeti DK, Evans SG, Roesch F, Howman-Giles R (2011) Potential use of 68Ga-apo-transferrin as a PET imaging agent for detecting Staphylococcus aureus infection. Nucl Med Biol 38:393–398
Kumar V, Boddeti DK, Evans SG, Angelides S (2012) 68Ga-citrate-PET for diagnostic imaging of infection in rats and for intra abdominal infection in a patient. Current radiopharmaceuticals 5:71–75
Larson SM (1978) Mechanisms of localization of gallium-67 in tumors. Semin Nucl Med 8:193–203
Lavender JP, Lowe J, Baker JR et al (1971) Gallium-67 citrate scanning in neoplastic and inflammatory lesions. Br J Radiol 44:361–366
Lisbona R, Derbekyan V, Novales-Diaz J et al (1993) Gallium-67 scintigraphy in tuberculous and nontuberculousn infectious spondylitis. J Nucl Med 34:853–859
Littenberg RL, Taketa RM, Alazraki NP et al (1973) Gallium-67 for localization of septic lesions. Ann Intern Med 79:403–406
Lim Y, Shin SH, Lee SI, Kim IS, Rhec JH (1998) Iron-repressibility of siderophore and transferrin-binding protein Staphylococcus aureus. FEMS Microbiol Lett 163:19–24
Lupetti A, Welling MM, Mazzi U et al (2002) Technetium-99m labelled fluconazole and antimicrobial peptides for imaging of Candida albicans and aspergillus fumigatus infections. Eur J Nucl Med Mol Imaging 29:674–679
Lupetti A, Nibbering PH, Welling MM, Pauwels EK (2003) Radiopharmaceuticals: new antimicrobial agents. Trends Biotechnol 21:70–73
Maecke HR, Andre JP (2007) 68Ga-PET radiopharmacy: a generator-based alternative to 18F-radiopharmacy. In: Schubiger PA, Lehmann L, Friebe M (eds) PET chemistry, the driving force in molecular imaging. Springer, New York, pp 215–241
Martinez JL, Delgado-Iribarren A, Baquero F (1990) Mechanisms of iron acquisition and bacterial virulence. FEMS Microbiol Rev 75:45–56
Makinen TJ, Lankinen P, Poyhonen T et al (2005) Comparison of 18F-FDG and 68Ga PET imaging in the assessment of experimental osteomyelitis due to Staphylococcus aureus. Eur J Nucl Med Mol Imaging 32:1259–1268
Ma LD, Frassica FJ, Bluemke DA, Fishman EK (1997) CT and MRI evaluation of musculoskeletal infection. Crit Rev Diagn Imaging 38:535–568
McAfee JG, Thakur ML (1976a) Survey of radioactive agents for in vitro labelling of phagocytic leukocytes I. Soluble agents. J Nucl Med 17:480–487
McAfee JG, Thakur ML (1976b) Survey of radioactive agents for in vitro labelling of phagocytic leukocytes II. Particles. J Nucl Med 17:488–492
Merkel KD, Brown ML, Fitzgerald RH Jr (1986) Sequential technetium-99m HMDP gallium-67 citrate imaging for the evaluation of infection in the painful prosthesis. J Nucl Med 27:1413–1417
Menon S, Wagner HN Jr, Tsan MF (1978) Studies on gallium-accumulation in inflammatory lesions II. Uptake by Staphylococcus aureus: concise communication. J Nucl Med 19:44–47
Mozley PD, Thakur ML, Alavi A et al (1999) Effects of a 99mTc-labeled murine immunoglobulin M antibody to CD15 antigens on human granulocyte membranes in healthy volunteers. J Nucl Med 40:2107–2114
Modic MT, Feiglin DH, Piraino DW et al (1985) Vertebral osteomyelitis: assessment using MR. Radiology 157:157–166
Moser E, Tatsch K, Kirsch C-M et al (1990) Value of 67gallium scintigraphy in primary diagnosis and follow-up of opportunistic pneumonia in patients with AIDS. Lung 168(suppl):692–703
Nakao A, Fujii T, Sugimoto H et al (2006) Oncological problems in pancreatic cancer surgery. World J Gastroenterol 12:4466–4472
Nanni C et al (2010) 68Ga-Citrate PET/CT for Evaluating Patients with Infections of the Bone. Preliminary results. J Nucl Med 51(12):1932–1936
Palestro CJ, Swyer AJ, Kim CK, Goldsmith SJ (1991) Infected knee prosthesis: diagnosis with In-Ill-leukocyte, Tc-99m sulfur colloid, and Tc-99m MDP imaging. Radiology 179:645–648
Palestro CJ (1994) The current role of gallium imaging in infection. Semin Nucl Med 24:128–141
Palestero CJ (2003) Nuclear medicine, the painful prosthetic joint, and orthopaedic infection. J Nucl Med 44:927–929
Peters AM (1994) The utility of 99mTc HMPAO-leukocytes for imaging infection. Semin Nucl Med 24:110–127
Petrik M, Haas H, Dobrozemsky G et al (2010) 68Ga-Siderophores for PET imaging of invasive pulmonary aspergillosis: proof of principle. J Nucl Med 51(4):639–645
Rinne J, Boddeti DK, Burchardt C, Kumar V, Angelides S, Roesch F (2010) Preparation of 68Ga-labelled glucosamine. Int Med J 40(Suppl 2):1–39 (Abstract)
Rizzello A, Di Pierro D, Lodi F et al (2009) Synthesis and quality control of 68Ga citrate for routine clinical PET. Nucl Med Comm 30:542–545
Riss PJ, Kroll C, Nagel V, Roesch F (2008) NODAPA-OH and NODAPA-(NCS)n: Synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging. Bioorg Med Chem Lett 18:5364–5367
Riss PJ, Burchrdt c, Roesch F (2011) A methodical 68Ga labeling study of DO2A-(butyl-L-tyrosine) 2 with cation-exchanger post-processed 68Ga: practical aspects of radiolabelling. Contrast Media Mol Imag 6:492–498
Roesch F, Riss PJ (2010) The renaissance of the 68Ge/68Ga radionuclide generator initiates new developments in 68Ga radiopharmaceutical chemistry. Curr Top Med Chem 10:1–35
Rösch F, Filosofov DV (2010) Production, radiochemical processing and quality evaluation of Ge-68 suitable for production of a 68Ge/68Ga generator. In: IAEA-TEC-DOC radioisotopes and radiopharmaceuticals, series 2: production and processing of parent radionuclides for generators: 68Ga, 82Sr, 90Sr, 188W for nuclear medicine applications, Int Atomic Energy Agency, Vienna ISBN 978-92-0-101110-7
Rösch F, Knapp FF (Russ) (2003) Radionuclide generators. In: Vértes A, Nagy S, Klencsár Z (eds) Handbook of nuclear chemistry. Kluwer Academic, Dordrecht, The Netherlands
Rufini V, Calcagni ML, Baum RP (2006) Imaging of neuroendocrine tumors. Semin Nucl Med 36:228–247
Rypins EB, Kipper SL, Weiland F et al (2002) 99mTc anti-CD 15 monoclonal antibody (LeuTech) imaging improves diagnostic accuracy and clinical management in patients with equivocal presentation of appendicitis. Ann Surg 235:232–239
Saif MW, Cornfeld D, Modarresifar H, Ojha B (2008) FDG positron emission tomography CT (FDG-PET-CT) in the management of pancreatic cancer: initial experience in 12 patients. J Gastrointest Liver Dis 17:173–178
Silberstein EB, Fernandez-Ulloa M, Hall J (1981) Are oral cathartics of value in optimizing the gallium scan? concise communication. J Nucl Med 22:424–427
Shulkin BL (1997) PET applications in pediatrics. Q J Nucl Med 41(4):281–291
Shongwe MS, Smith CA, Ainscough EW et al (1992) Anion binding by human lactoferrin: results from crystallographic and physicochemical studies. Biochemistry 31:4451–4458
Siaens R, Eijsink VG, Dierckx R, Slegers G (2004) 123I-Labeled chitinase as specific radioligand for in vivo detection of fungal infections in mice. J Nucl Med 45:1209–1216
Skehan SJ, White JF, Evans JW et al (2003) Mechanism of accumulation of 99mTc-sulesomab in inflammation. J Nucl Med 44:11–18
Stumpe KD, Dazzi H, Schaffner A, von Schulthess GK (2000) Infection imaging using whole-body FDG-PET. Eur J Nucl Med 27:822–832
Sugawara Y, Gutowski TD, Fisher SJ et al (1999) Uptake of positron emission tomography tracers in experimental bacterial infections: a comparative biodistribution study of radiolabeled FDG, thymidine, l-methionine, 67Ga-citrate, and 125I-HSA. Eur J Nucl Med 26:333–341
Tatsch K, Knesewitsch P, Matuschke A et al (1990) 67Ga-scintigraphy for evaluation of AIDS-related intestinal infections. Nucl Med Commun 11:649–655
Termaat MF, Raijmakers PG, Scholten HJ et al (2005) The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis. J Bone Jt Surg Am 87:2464–2471
Thakur ML, Richard MD, White FW III (1988) Monoclonal antibodies as agents for selective radiolabeling of human neutrophils. J Nucl Med 29:1817–1825
Thakur ML, Marcus CS, Henneman P et al (1996) Imaging inflammatory diseases with neutrophil-specific technetium-99m-labeled monoclonal antibody anti-SSEA-1. J Nucl Med 37:1789–1795
Tsan MF (1985) Mechanism of gallium-67 accumulation in inflammatory lesions. J Nucl Med 26:88–92
Tulchinsky M, Peters AM (2005) Leukocyte receptor-binding radiopharmaceuticals for infection and inflammation scintigraphy. J Nucl Med 46:718–721
Tzen KY, Oster ZH, Wagner HN Jr, Tsan MF (1980) Role of iron-binding proteins and enhanced capillary permeability on the accumulation of gallium-67. J Nucl Med 21:31–35
Ujula T, Salomäki S, Autio A et al (2009) 68Ga-chloride PET reveals human pancreatic adenocarcinoma xenografts in rats—comparison with FDG. Mol Imaging Biol 12:259–268
van Eerd JE, Oyen WJ, Harris TD et al (2003) A bivalent leukotriene B(4) antagonist for scintigraphic imaging of infectious foci. J Nucl Med 44:1087–1091
Velikyan I et al (2004) Microwave-supported preparation of 68Ga bioconjugates with high specific radioactivity. Bioconjugate Chem 15:554–560
Vinjamuri S, Hall AV, Solanki KK, Bomanji J, Siraj Q, O’Shaughnessy E et al (1996) Comparison of 99mTc infecton imaging with radiolabelled white-cell imaging in the evaluation of bacterial infection. Lancet 347:233–235
Weber WA, Schwaiger M, Avril N (2000) Quantitative assessment of tumor metabolism using FDG-PET imaging. Nucl Med Biol 27(7):683–687
Weiner R, Hoffer PB, Thakur ML (1981) Lactoferrin: its role as a 67Ga-binding protein in polymorphonuclear leukocytes. J Nucl Med 22:32–37
Welling MM, Paulusma-Annema A, Balter HS et al (2000) Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med 27:292–301
Welling MM, Mongera S, Lupetti A et al (2002) Radiochemical and biological characteristics of 99mTc-UBI 29–41 for imaging of bacterial infections. Nucl Med Biol 29:413–422
Yang DJ, Kim CG, Schechter NR, Azhdarinia A et al (2003) Imaging with 99mTc-ECDG targeted at the multifunctional glucose transport system: feasibility study with rodents. Radiology 226:465–473
Yang DJ, Yukihiro M, Podoloff DA et al (2004) Assessment of therapeutic tumor response using 99mTc-ethylenedicysteine-glucosamine. Cancer Biother Radiopharm 19:443–456
Zhernosekov KP, Filosofov DV, Baum RP et al (2007) Processing of generator produced 68Ga for medical application. J Nucl Med 48:1741–1748
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Kumar, V., Boddeti, D.K. (2013). 68Ga-Radiopharmaceuticals for PET Imaging of Infection and Inflammation. In: Baum, R., Rösch, F. (eds) Theranostics, Gallium-68, and Other Radionuclides. Recent Results in Cancer Research, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27994-2_11
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